DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and prkcda

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_999873.1	Gene:	prkcda / 334571	ZFINID:	ZDB-GENE-030131-6503	Length:	684	Species:	Danio rerio

Alignment Length:	525	Identity:	158/525 - (30%)
Similarity:	246/525 - (46%)	Gaps:	87/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGD---DATGN---GSSHQ----DDGDESV- 207
            |..|.||:.:.:  ....:...|:.| :..|.|:...   |..|:   |...|    :|...:|
Zfish   209 CTGTAANSRDTM--FQKERFKIDMPH-RFKTNNYMSPTFCDHCGSLLWGLVKQGLKCEDCSMNVH 270

  Fly   208 -KCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSGGKDIFAQCVNA 271
             |||.                 |...:.|...:|:.:.|     .||..|.::...|...|.|..
Zfish   271 HKCQT-----------------KVANLCGINQKLLAEAL-----TQVSTKSSTKRPDNNTQDVGV 313

  Fly   272 VKAFLAGEPFREFESSMYFHRYLQWKWLEAQP---ITYKT------FRMYRVLGKGGFGEVCACQ 327
            .:.|.........:.:.|.|   .|:....:|   ||::|      |..::|||||.||:|...:
Zfish   314 YQDFNKSPGPDVTDGTPYGH---IWEGSSPRPPSRITHQTRITAEHFIFHKVLGKGSFGKVLLAE 375

  Fly   328 VRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKI-NSPFVVNLAYAYETKDALCLVLTIMNG 391
            ::.||:.:|.|.|:|..:.........::||::|... ::||:.:|...::||:.|..|:..:||
Zfish   376 LKGTGEWFAVKALKKDVVLMDDDVECTMVEKRVLALAWDNPFLTHLYSTFQTKEHLFFVMEYLNG 440

  Fly   392 GDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGL 456
            |||.|||...|   .|:|.||.|||||:.||||.||.:||:|||.|.:|::||..||::|:|.|:
Zfish   441 GDLMFHIQEKG---RFDLYRATFYAAEIVCGLQFLHSKGIIYRDLKLDNVMLDGDGHIKIADFGM 502

  Fly   457 AVEIPEGEMVRGRV----GTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVK 517
            ..|...|:   .|.    ||..|:|||::..::|:||.||:|||.|:|||:.||:||....|
Zfish   503 CKENVFGD---NRATTFCGTPDYIAPEILLGQQYSFSVDWWSFGVLVYEMLIGQSPFHGDDE--- 561

  Fly   518 REEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWR 582
             :|:...::.|...|......:.:.|.::|..:...:|||.    :|  ::..|.||.:  :||.
Zfish   562 -DELFESIRMDTPHYPRWILLDTRDMLERLFERDPSRRLGI----VG--NIRGHSFFKT--VNWA 617

  Fly   583 RLEAGMLEPPFVPDPHAVYAKDVLDIEQFS-------TVKGVNIDESDTNFYTKFNTGSVSISWQ 640
            .||...::|||.|...|.......|.|..|       ..||: ||..|...:..|       |:.
Zfish   618 ALEGREVDPPFKPKVKAPNDCSNFDREFLSEKPRLSHCEKGL-IDSMDQCAFAGF-------SFI 674

  Fly   641 NEMME 645
            |..||
Zfish   675 NPKME 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	11/59 (19%)
		STKc_GRK4_like	308..597	CDD:270756	110/299 (37%)
		S_TKc	309..574	CDD:214567	99/269 (37%)
prkcda	NP_999873.1	C1_1	160..209	CDD:278556	158/525 (30%)
		C1_1	232..284	CDD:278556	14/69 (20%)
		S_TKc	357..611	CDD:214567	99/269 (37%)
		STKc_nPKC_delta	361..676	CDD:173710	119/340 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910