Protein Alignment Gprk2 and Grk3

DIOPT Version :9

• Sequence 1: NP_001263143.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_796052.2
• Gene: Grk3 / 320129
• MGIID: 87941
• Length: 688
• Species: Mus musculus
• Alignment Length: 654
• Identity: 198/654 - (30%)
• Similarity: 301/654 - (46%)
• Gaps: 141/654 - (21%)

  Fly     2 ELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCIN--LKDKLDISYGYVIDQQPIGR 64
            :||.::|:..||.|.|....:...::.| :.:|..|.|...:.  |.::.:|::..:.:|: ||.
Mouse     3 DLEAVLADVSYLMAMEKSKTAPAARASK-KVVLPEPSIRSVMQRYLAERNEITFDKIFNQK-IGF 65

  Fly    65 ELFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALD 129
            .||:.||.|:.......:.|.:|:.:||                 .||.|   |.|........|
Mouse    66 LLFKDFCLNEIGEAVPQVKFYEEIKEYE-----------------KLDNE---EDRLRRSRQMYD 110

  Fly   130 AETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATG 194
            |....|||   |:.:.......||..:                |.|    ||..|       ||
Mouse   111 AYIMRELL---SSTHQFSKQAVEHVQS----------------HLS----KKQVT-------AT- 144

  Fly   195 NGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNS 259
                                                                             
Mouse   145 ----------------------------------------------------------------- 144

  Fly   260 GGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQ-PITYKTFRMYRVLGKGGFGEV 323
                :|...:..:...|.|:.|::|..|..|.|:.|||.:|.. .::...|.::|::|:||||||
Mouse   145 ----LFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLSMNDFSVHRIIGRGGFGEV 205

  Fly   324 CACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINS---PFVVNLAYAYETKDALCLV 385
            ..|:...||||||.|.|:|||:|.::||::.|.|:.:|..:::   ||:|.:.||:.|.|.||.:
Mouse   206 YGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI 270

  Fly   386 LTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVR 450
            |.:|||||:.:|:...|   .|..:..||||:|:..||:|:|...:||||.||.|||||::||||
Mouse   271 LDLMNGGDMHYHLSQHG---VFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVR 332

  Fly   451 ISDLGLAVEIPEGEMVRGRVGTVGYMAPEVIDNEK-YAFSPDWFSFGCLLYEMIEGQAPFRMRKE 514
            |||||||.:..: :.....|||.|||||||:.... |..|.||||.||:|::::.|.:|||..|.
Mouse   333 ISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHSPFRQHKT 396

  Fly   515 KVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQL 579
            |.| .|:||.......:....|:.|.:|:.:.||.:.:.|||||..|  |.:::..|.||..  :
Mouse   397 KDK-HEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCGGG--GARELKEHIFFKG--I 456

  Fly   580 NWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQF--STVKGVNIDESDTNFYTKFNTGSVSISWQNE 642
            :|:.:......||.:|....|.|.|..||..|  ...||:.:.:.|.:.|..|.. .:|..||.|
Mouse   457 DWQHVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPL-VISERWQQE 520

  Fly   643 MMET 646
            ::||
Mouse   521 VVET 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	16/77 (21%)
		RGS	<248..305	CDD:295367	12/57 (21%)
		STKc_GRK4_like	308..597	CDD:270756	124/292 (42%)
		S_TKc	309..574	CDD:214567	118/268 (44%)
Grk3	NP_796052.2	N-terminal	1..190		57/308 (19%)
		RGS_GRK2_GRK3	30..186	CDD:188701	50/277 (18%)
		PKc_like	185..530	CDD:304357	141/350 (40%)
		Pkinase	191..453	CDD:278497	118/268 (44%)
		PH_GRK2_subgroup	553..670	CDD:269946
		PH	560..647	CDD:278594

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820