DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and Rps6ka6

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001178650.1	Gene:	Rps6ka6 / 317203	RGDID:	1560817	Length:	860	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	118/344 - (34%)
Similarity:	188/344 - (54%)	Gaps:	39/344 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 VNAVKAFLAGEPFREFE----------SSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEV 323
            ||.:|  :..||..|.|          ..:...::::..:.:|.|   ..|.:.:|||:|.||:|
  Rat   145 VNDLK--MVDEPMDEGEPVFCRREDLVKEIPITQHVKEGYEKADP---AQFDLLKVLGQGSFGKV 204

  Fly   324 CACQVRA---TGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLV 385
            ...:.:.   .|::||.|.|.|..:|.| ......:|:.||.::|.||:|.|.||::|:..|.|:
  Rat   205 FLVRKKTGPDAGQLYAMKVLRKASLKVR-DRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLI 268

  Fly   386 LTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVR 450
            |..:.|||:   ...:..|..|..|..:||.||:|..|.|||:.||||||.||||||||:.||::
  Rat   269 LDFLRGGDV---FTRLSKEVLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIK 330

  Fly   451 ISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKE 514
            ::|.||:.| :.:.:......|||.||||||::...::.|.||:|:|.|::||:.|..||   :.
  Rat   331 LTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPF---QG 392

  Fly   515 KVKREEVDRRVKED---PEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHS 576
            |.:.|.::..:|..   |:..|:    ||:|:.:.|..::...|||..    |.::|..|.||.|
  Rat   393 KDRNETMNMILKAKLGMPQFLSA----EAQSLLRMLFKRNPANRLGSE----GVEEVKRHAFFSS 449

  Fly   577 TQLNWRRLEAGMLEPPFVP 595
              ::|.:|....::|||.|
  Rat   450 --IDWNKLYKREVQPPFRP 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	9/45 (20%)
		STKc_GRK4_like	308..597	CDD:270756	109/295 (37%)
		S_TKc	309..574	CDD:214567	100/271 (37%)
Rps6ka6	NP_001178650.1	S_TKc	190..447	CDD:214567	100/271 (37%)
		STKc_RSK_N	194..508	CDD:270734	108/290 (37%)
		STKc_RSK_C	543..829	CDD:270993
		Pkinase	543..800	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910