DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and Prkacb

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_006233513.1	Gene:	Prkacb / 293508	RGDID:	1310574	Length:	398	Species:	Rattus norvegicus

Alignment Length:	327	Identity:	103/327 - (31%)
Similarity:	174/327 - (53%)	Gaps:	33/327 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 EPFREF--ESSMYFHRYLQWKWLEAQPIT--YKTFRMYRVLGKGGFGEVCACQVRATGKMYACKK 339
            :|.:||  ::...|.|    ||....|..  .:.|...:.||.|.||.|...:.:||.:.||.|.
  Rat    61 KPMKEFLAKAKEDFLR----KWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI 121

  Fly   340 LEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG-- 402
            |:|:::.|.|.....|.||:|||.:..||:|.|.|:::....|.:|:..:.||::..|:..:|
  Rat   122 LDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRF 186

  Fly   403 GEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMVR 467
            .||     .||||||::....::||...::|||.||||:|:|..|:::::|.|.|      :.|:
  Rat   187 SEP-----HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA------KRVK 240

  Fly   468 GRV----GTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKED 528
            ||.    ||..|:|||:|.::.|..:.||::.|.|:|||..|..|| ...:.:   ::..::...
  Rat   241 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF-FADQPI---QIYEKIVSG 301

  Fly   529 PEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPF 593
            ..::.|.|:.:.|.:.:.||...:.:|.|  |.:.|..|:..|.:|.:|  :|..:....:|.||
  Rat   302 KVRFPSHFSSDLKDLLRNLLQVDLTKRFG--NLKNGVSDIKTHKWFATT--DWIAIYQRKVEAPF 362

  Fly   594 VP 595
            :|
  Rat   363 IP 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	8/27 (30%)
		STKc_GRK4_like	308..597	CDD:270756	95/294 (32%)
		S_TKc	309..574	CDD:214567	88/270 (33%)
Prkacb	XP_006233513.1	PTZ00263	79..398	CDD:140289	96/305 (31%)
Prkacb	XP_006233513.1	STKc_PKA	89..378	CDD:271111	95/295 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910