| Sequence 1: | NP_001263143.1 | Gene: | Gprk2 / 49045 | FlyBaseID: | FBgn0261988 | Length: | 714 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_005299.1 | Gene: | GRK5 / 2869 | HGNCID: | 4544 | Length: | 590 | Species: | Homo sapiens |
| Alignment Length: | 719 | Identity: | 381/719 - (52%) |
|---|---|---|---|
| Similarity: | 459/719 - (63%) | Gaps: | 134/719 - (18%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
Fly 66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
Fly 131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195
Fly 196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNK-LNS 259
Fly 260 GGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVC 324
Fly 325 ACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIM 389
Fly 390 NGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDL 454
Fly 455 GLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKRE 519
Fly 520 EVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRL 584
Fly 585 EAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECF 649
Fly 650 RELNVFGPEECPTPDLQINAAPEPDKAGCFP--FRRKKKQPARTQPIPIP--EHLLTTSHSVSST 710
Fly 711 TVES 714 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Gprk2 | NP_001263143.1 | RGS | 35..>111 | CDD:295367 | 32/75 (43%) |
| RGS | <248..305 | CDD:295367 | 28/57 (49%) | ||
| STKc_GRK4_like | 308..597 | CDD:270756 | 218/288 (76%) | ||
| S_TKc | 309..574 | CDD:214567 | 202/264 (77%) | ||
| GRK5 | NP_005299.1 | N-terminal | 1..185 | 96/307 (31%) | |
| Interaction with calmodulin | 20..39 | 11/18 (61%) | |||
| RGS_GRK5 | 53..175 | CDD:188706 | 53/245 (22%) | ||
| STKc_GRK5 | 183..495 | CDD:270780 | 240/316 (76%) | ||
| S_TKc | 186..448 | CDD:214567 | 202/264 (77%) | ||
| Nuclear localization signal. /evidence=ECO:0000269|PubMed:15542828 | 388..395 | 6/6 (100%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 531..590 | 16/58 (28%) | |||
| Sufficient for membrane localization | 546..565 | 4/18 (22%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165154966 | |
| Domainoid | 1 | 1.000 | 417 | 1.000 | Domainoid score | I650 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG0986 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H3879 | |
| Inparanoid | 1 | 1.050 | 698 | 1.000 | Inparanoid score | I681 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S1218 |
| OMA | 1 | 1.010 | - | - | QHG47927 | |
| OrthoDB | 1 | 1.010 | - | - | D1104340at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001059 | |
| OrthoInspector | 1 | 1.000 | - | - | otm42305 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_102122 | |
| Panther | 1 | 1.100 | - | - | O | PTHR24355 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R4592 |
| SonicParanoid | 1 | 1.000 | - | - | X940 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 17 | 16.750 | |||||