DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gprk2 and GRK4

DIOPT Version :9

Sequence 1:NP_001263143.1 Gene:Gprk2 / 49045 FlyBaseID:FBgn0261988 Length:714 Species:Drosophila melanogaster
Sequence 2:XP_011511749.1 Gene:GRK4 / 2868 HGNCID:4543 Length:617 Species:Homo sapiens


Alignment Length:707 Identity:332/707 - (46%)
Similarity:409/707 - (57%) Gaps:166/707 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            |||||||||::.||||:||.....|:||||::||..|.:|||..|:..::..|..:.|:|||||.
Human     1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRR 65

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            |||.||:.| |...|:|.|||.|.:||:                     |..|.|:..|...||.
Human    66 LFRQFCDTK-PTLKRHIEFLDAVAEYEV---------------------ADDEDRSDCGLSILDR 108

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195
            ...::|                                                           
Human   109 FFNDKL----------------------------------------------------------- 114

  Fly   196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSG 260
                                              ..|:...|.::|.:       .::..|..:.
Human   115 ----------------------------------AAPLPEIPPDVVTE-------CRLGLKEENP 138

  Fly   261 GKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGE--- 322
            .|..|.:|......:|.||||.|::.|.||.::|||||||.||:|..|||.|||||||||||   
Human   139 SKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEQSP 203

  Fly   323 ------------------------------------VCACQVRATGKMYACKKLEKKRIKKRKGE 351
                                                ||||||||||||||||||:||||||||||
Human   204 VGCAVDGSWKKQQPNVDDTEARGPEPEAHDTIFSTFVCACQVRATGKMYACKKLQKKRIKKRKGE 268

  Fly   352 SMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYA 416
            :|.|.||:||:|:.|.|||:|||||||||||||||||||||||||||||: |.|||:.:||.|||
Human   269 AMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL-GNPGFDEQRAVFYA 332

  Fly   417 AEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVI 481
            ||:.|||:.|.::.|||||.|||||||||.||:||||||||.|||||:.|||||||||||||||:
Human   333 AELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVV 397

  Fly   482 DNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQ 546
            :||||.|||||:..|||:||||:|.:||:..|||||.||||:|:|.|.|:||.||:::|||:|:.
Human   398 NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRM 462

  Fly   547 LLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQF 611
            ||.|:..:|||||.  .|...|..||.|  ..:|:|||||.||||||.|||||||.|||||||||
Human   463 LLTKNPSKRLGCRG--EGAAGVKQHPVF--KDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQF 523

  Fly   612 STVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECFRELNVFGPEECPTPDLQIN 668
            |.|||:.:|.:|.:||.:|.||.|||.|||||:|:.||:::|....||....||..|
Human   524 SVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKN 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk2NP_001263143.1 RGS 35..>111 CDD:295367 27/75 (36%)
RGS <248..305 CDD:295367 22/56 (39%)
STKc_GRK4_like 308..597 CDD:270756 207/327 (63%)
S_TKc 309..574 CDD:214567 192/303 (63%)
GRK4XP_011511749.1 RGS 52..184 CDD:295367 54/253 (21%)
STKc_GRK4 186..509 CDD:173720 207/327 (63%)
S_TKc 187..488 CDD:214567 192/303 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154965
Domainoid 1 1.000 417 1.000 Domainoid score I650
eggNOG 1 0.900 - - E1_KOG0986
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 698 1.000 Inparanoid score I681
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47927
OrthoDB 1 1.010 - - D1104340at2759
OrthoFinder 1 1.000 - - FOG0001059
OrthoInspector 1 1.000 - - otm42305
orthoMCL 1 0.900 - - OOG6_102122
Panther 1 1.100 - - LDO PTHR24355
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4592
SonicParanoid 1 1.000 - - X940
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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