Protein Alignment Gprk2 and Grk3

DIOPT Version :9

• Sequence 1: NP_001263143.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_037029.2
• Gene: Grk3 / 25372
• RGDID: 2063
• Length: 688
• Species: Rattus norvegicus
• Alignment Length: 654
• Identity: 196/654 - (29%)
• Similarity: 299/654 - (45%)
• Gaps: 141/654 - (21%)

  Fly     2 ELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCIN--LKDKLDISYGYVIDQQPIGR 64
            :||.::|:..||.|.|....:...::.| :.:|..|.|...:.  |.::.:|::..:.:|: ||.
  Rat     3 DLEAVLADVSYLMAMEKSKAAPAARASK-KVVLPEPSIRSVMQRYLAERNEITFDKIFNQK-IGF 65

  Fly    65 ELFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALD 129
            .||:.||.|:.......:.|.:|:.:||                 .||.|   |.|........|
  Rat    66 LLFKDFCLNEIGEAVPQVKFYEEIKEYE-----------------KLDNE---EDRLHRSRQMYD 110

  Fly   130 AETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATG 194
            |....|||   |:.:.......||..:                |.|    ||..|
  Rat   111 AYIMRELL---SSTHQFSKQAVEHVQS----------------HLS----KKQVT---------- 142

  Fly   195 NGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNS 259
                                                                             
  Rat   143 ----------------------------------------------------------------- 142

  Fly   260 GGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQ-PITYKTFRMYRVLGKGGFGEV 323
              ..:|...:..:...|.|:.|::|..|..|.|:.|||.:|.. .::...|.::|::|:||||||
  Rat   143 --PTLFQPYIEEICESLRGDIFQKFMESEKFTRFCQWKNVELNIHLSMNDFSVHRIIGRGGFGEV 205

  Fly   324 CACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINS---PFVVNLAYAYETKDALCLV 385
            ..|:...||||||.|.|:|||:|.::||::.|.|:.:|..:::   ||:|.:.||:.|.|.||.:
  Rat   206 YGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI 270

  Fly   386 LTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVR 450
            |.:|||||:.:|:...|   .|..:..||||:|:..||:|:|...:||||.||.|||||::||||
  Rat   271 LDLMNGGDMHYHLSQHG---VFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVR 332

  Fly   451 ISDLGLAVEIPEGEMVRGRVGTVGYMAPEVIDNEK-YAFSPDWFSFGCLLYEMIEGQAPFRMRKE 514
            |||||||.:..: :.....|||.|||||||:.... |..|.||||.||:|::::.|.:|||..|.
  Rat   333 ISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHSPFRQHKT 396

  Fly   515 KVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQL 579
            |.| .|:||.......:....|:.|.:|:.:.||.:.:.|||||..|  |.:::..|.||..  :
  Rat   397 KDK-HEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCCGG--GARELKEHIFFKG--I 456

  Fly   580 NWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQF--STVKGVNIDESDTNFYTKFNTGSVSISWQNE 642
            :|:.:......||.:|....|.|.|..||..|  ...||:.:.:.|.:.|..|.. .:|..||.|
  Rat   457 DWQYVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPL-VISERWQQE 520

  Fly   643 MMET 646
            ::||
  Rat   521 VVET 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	16/77 (21%)
		RGS	<248..305	CDD:295367	12/57 (21%)
		STKc_GRK4_like	308..597	CDD:270756	124/292 (42%)
		S_TKc	309..574	CDD:214567	118/268 (44%)
Grk3	NP_037029.2	N-terminal	1..190		55/308 (18%)
		RGS_GRK2_GRK3	30..186	CDD:188701	48/277 (17%)
		PKc_like	185..530	CDD:419665	141/350 (40%)
		PH_GRK2_subgroup	553..670	CDD:269946

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920