Protein Alignment Gprk2 and Grk2

DIOPT Version :9

• Sequence 1: NP_001263143.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_036908.2
• Gene: Grk2 / 25238
• RGDID: 2062
• Length: 689
• Species: Rattus norvegicus
• Alignment Length: 658
• Identity: 208/658 - (31%)
• Similarity: 309/658 - (46%)
• Gaps: 149/658 - (22%)

  Fly     2 ELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCIN--LKDKLDISYGYVIDQQPIGR 64
            :||.::|:..||.|.|....:...::.| :.:|..|.|...:.  |:|:.::::..:..|: :|.
  Rat     3 DLEAVLADVSYLMAMEKSKATPAARASK-KILLPEPSIRSVMQKYLEDRGEVTFEKIFSQK-LGY 65

  Fly    65 ELFRLFC----ENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGG 125
            .|||.||    |..:|:    :.|.:|:.|||                 .|:.|.:..:|:   .
  Rat    66 LLFRDFCLNHLEEAKPL----VEFYEEIKKYE-----------------KLETEEERVVRS---R 106

  Fly   126 DALDAETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGD 190
            :..|:...:|||..|   :|.....|||.
  Rat   107 EIFDSYIMKELLACS---HPFSKNATEHV------------------------------------ 132

  Fly   191 DATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRN 255
                                :||  ..|          |.||
  Rat   133 --------------------QGH--LVK----------KQVP----------------------- 142

  Fly   256 KLNSGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQ-PITYKTFRMYRVLGKGG 319
                  .|:|...:..:...|.|:.|.:|..|..|.|:.|||.:|.. .:|...|.::|::|:||
  Rat   143 ------PDLFQPYIEEICQNLRGDVFHKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGG 201

  Fly   320 FGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINS---PFVVNLAYAYETKDA 381
            ||||..|:...||||||.|.|:|||||.::||::.|.|:.:|..:::   ||:|.::||:.|.|.
  Rat   202 FGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDK 266

  Fly   382 LCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDH 446
            |..:|.:||||||.:|:...|   .|.....||||||:..||:|:|.:.:||||.||.|||||:|
  Rat   267 LSFILDLMNGGDLHYHLSQHG---VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEH 328

  Fly   447 GHVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVID-NEKYAFSPDWFSFGCLLYEMIEGQAPFR 510
            |||||||||||.:..: :.....|||.|||||||:. ...|..|.||||.||:|::::.|.:|||
  Rat   329 GHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392

  Fly   511 MRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFH 575
            ..|.|.| .|:||.......:....|:.|.:|:.:.||.:.:.:||||. || |.|:|...|||.
  Rat   393 QHKTKDK-HEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCL-GR-GAQEVKESPFFR 454

  Fly   576 STQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQF--STVKGVNIDESDTNFYTKFNTGSVSIS 638
            |  |:|:.:......||.:|....|.|.|..||..|  ...||:.:.:||...|..|.. ::|..
  Rat   455 S--LDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISER 516

  Fly   639 WQNEMMET 646
            ||.|:.||
  Rat   517 WQQEVAET 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	18/81 (22%)
		RGS	<248..305	CDD:295367	13/57 (23%)
		STKc_GRK4_like	308..597	CDD:270756	131/292 (45%)
		S_TKc	309..574	CDD:214567	123/268 (46%)
Grk2	NP_036908.2	N-terminal	1..190		59/312 (19%)
		RGS_GRK2_GRK3	30..186	CDD:188701	51/281 (18%)
		STKc_GRK2	190..510	CDD:271125	142/328 (43%)
		PH_GRK2_subgroup	553..670	CDD:269946

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750