DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and Akt1

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_150233.1	Gene:	Akt1 / 24185	RGDID:	2081	Length:	480	Species:	Rattus norvegicus

Alignment Length:	359	Identity:	118/359 - (32%)
Similarity:	184/359 - (51%)	Gaps:	48/359 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 AQP---ITYKTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQ 362
            |:|   :|...|...::||||.||:|...:.:|||:.||.|.|:|:.|..:...:..|.|.::||
  Rat   139 AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203

  Fly   363 KINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLH 427
            ....||:..|.|:::|.|.||.|:...|||:|.||   :..|..|..:|||||.||:...|.:||
  Rat   204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH---LSRERVFSEDRARFYGAEIVSALDYLH 265

  Fly   428 -KQGIVYRDCKPENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSP 490
             ::.:||||.|.||::||..||::|:|.||..| |.:|..::...||..|:||||:::..|..:.
  Rat   266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330

  Fly   491 DWFSFGCLLYEMIEGQAPFRMRK-----EKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAK 550
            ||:..|.::|||:.|:.||..:.     |.:..||:         ::......||||:...||.|
  Rat   331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI---------RFPRTLGPEAKSLLSGLLKK 386

  Fly   551 SIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVK 615
            ...||||  .|....:::|.|.||  ..:.|:.:....|.|||.|..
  Rat   387 DPTQRLG--GGSEDAKEIMQHRFF--ANIVWQDVYEKKLSPPFKPQV------------------ 429

  Fly   616 GVNIDESDTNFY-TKFNTGSVSISWQNEMMETEC 648
               ..|:||.:: .:|....::|:..::....||
  Rat   430 ---TSETDTRYFDEEFTAQMITITPPDQDDSMEC 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	2/6 (33%)
		STKc_GRK4_like	308..597	CDD:270756	108/295 (37%)
		S_TKc	309..574	CDD:214567	100/271 (37%)
Akt1	NP_150233.1	PH_PKB	4..111	CDD:269947
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	14..19
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	23..25
		STKc_PKB_alpha	124..479	CDD:270746	118/359 (33%)
		Inhibitor binding. /evidence=ECO:0000250	228..230		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..480		2/10 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910