DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and STK32A

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001274669.1	Gene:	STK32A / 202374	HGNCID:	28317	Length:	407	Species:	Homo sapiens

Alignment Length:	314	Identity:	98/314 - (31%)
Similarity:	167/314 - (53%)	Gaps:	15/314 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 EAQPITYKTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKI 364
            |.:.:.:..|.:.|.:|||.||:||..|...|.||||.|.:.|::..:|.....|..|.||:|.:
Human    14 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 78

  Fly   365 NSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQ 429
            ..||:|||.|:::.::.:.:|:.::.||||::|:..   ...|:.|..:.:..|:...|.:|..|
Human    79 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ---NVHFKEETVKLFICELVMALDYLQNQ 140

  Fly   430 GIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVIDNEK---YAFSPD 491
            .|::||.||:|||||:||||.|:|..:|..:|....:....||..|||||:..:.|   |:|:.|
Human   141 RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVD 205

  Fly   492 WFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRL 556
            |:|.|...||::.|:.|:.:| .....:|:....:.....|.|.::.|..|:.::||..:..||.
Human   206 WWSLGVTAYELLRGRRPYHIR-SSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRF 269

  Fly   557 GCRNGRMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQ 610
            ...:      ||...|:.:  .:||..:....|.|.|:|:...:......::|:
Human   270 SQLS------DVQNFPYMN--DINWDAVFQKRLIPGFIPNKGRLNCDPTFELEE 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	1/4 (25%)
		STKc_GRK4_like	308..597	CDD:270756	96/291 (33%)
		S_TKc	309..574	CDD:214567	90/267 (34%)
STK32A	NP_001274669.1	STKc_Yank1	22..281	CDD:270730	90/268 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910