DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and Prkch

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_032882.2	Gene:	Prkch / 18755	MGIID:	97600	Length:	683	Species:	Mus musculus

Alignment Length:	364	Identity:	120/364 - (32%)
Similarity:	180/364 - (49%)	Gaps:	52/364 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKI-NSPFVVNL 372
            |...||||||.||:|...:::.||::||.|.|:|..|.:.......:.||:||... |.||:..|
Mouse   355 FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQL 419

  Fly   373 AYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCK 437
            ...::|.|.|..|:..:|||||.|||..   ...|:..||||||||:...|..||::||:|||.|
Mouse   420 FCCFQTPDRLFFVMEFVNGGDLMFHIQK---SRRFDEARARFYAAEIISALMFLHEKGIIYRDLK 481

  Fly   438 PENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYE 501
            .:|:|||..||.:::|.|:..| |..|.......||..|:|||::....|..:.||::.|.||||
Mouse   482 LDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYE 546

  Fly   502 MIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQ 566
            |:.|.|||....|    :::...:..|...|.:..:::|..:.:..:.|:...|||...  .||:
Mouse   547 MLCGHAPFEAENE----DDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLT--QGGE 605

  Fly   567 -DVMAHPFFHSTQLNWRRLEAGMLEPPFVP-----------DPHAVYAKDVLDIEQFSTVKGVNI 619
             :::.||||  .:::|.:|....|||||.|           ||..:..:.||
Mouse   606 HEILRHPFF--KEIDWAQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEEPVL------------- 655

  Fly   620 DESDTNFYTKFNTGSVSISWQNEMMETECFRELNVFGPE 658
                    |..:.|.:.:..|:|      ||..:...||
Mouse   656 --------TPIDEGHLPMINQDE------FRNFSYVSPE 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367
		STKc_GRK4_like	308..597	CDD:270756	108/301 (36%)
		S_TKc	309..574	CDD:214567	98/267 (37%)
Prkch	NP_032882.2	C2_PKC_epsilon	8..140	CDD:175981
		C1_1	172..222	CDD:365894
		C1_1	246..296	CDD:365894
		STKc_nPKC_eta	359..681	CDD:270742	119/360 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910