DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and Prkaca

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_032880.1	Gene:	Prkaca / 18747	MGIID:	97592	Length:	351	Species:	Mus musculus

Alignment Length:	393	Identity:	110/393 - (27%)
Similarity:	189/393 - (48%)	Gaps:	64/393 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 AVKAFL--AGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCACQVRATGK 333
            :||.||  |.|.|.:           :|:...........|...:.||.|.||.|...:.:.:|.
Mouse    15 SVKEFLAKAKEDFLK-----------KWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGN 68

  Fly   334 MYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 398
            .||.|.|:|:::.|.|.....|.||:|||.:|.||:|.|.::::....|.:|:..:.||::..|:
Mouse    69 HYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHL 133

  Fly   399 YNMG--GEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIP 461
            ..:|  .||     .||||||::....::||...::|||.||||:|:|..|:::::|.|.|
Mouse   134 RRIGRFSEP-----HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA---- 189

  Fly   462 EGEMVRGRV----GTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVD 522
              :.|:||.    ||..|:|||:|.::.|..:.||::.|.|:|||..|..|| ...:.:   ::.
Mouse   190 --KRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF-FADQPI---QIY 248

  Fly   523 RRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLEAG 587
            .::.....::.|.|:.:.|.:.:.||...:.:|.|  |.:.|..|:..|.:|.:|  :|..:...
Mouse   249 EKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFG--NLKNGVNDIKNHKWFATT--DWIAIYQR 309

  Fly   588 MLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECFREL 652
            .:|.||:|                 ..||    ..||:.:..:....:.:|     :..:|.:|.
Mouse   310 KVEAPFIP-----------------KFKG----PGDTSNFDDYEEEEIRVS-----INEKCGKEF 348

  Fly   653 NVF 655
            ..|
Mouse   349 TEF 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	8/35 (23%)
		STKc_GRK4_like	308..597	CDD:270756	94/294 (32%)
		S_TKc	309..574	CDD:214567	87/270 (32%)
Prkaca	NP_032880.1	STKc_PKA	42..331	CDD:271111	98/328 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910