DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and grk-1

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_509676.1	Gene:	grk-1 / 181212	WormBaseID:	WBGene00001708	Length:	642	Species:	Caenorhabditis elegans

Alignment Length:	730	Identity:	346/730 - (47%)
Similarity:	440/730 - (60%)	Gaps:	146/730 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            ||:|||||||||:||||.|. ..|||||||:..|||||.::|:.||.:::::|.:|:::||||:.
Worm     1 MEIENIVANTVYIKARESGG-QKKGKSKKWKNYLQFPHYTECLPLKTEIEVTYAFVVEKQPIGKL 64

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            ||..||:.....|.:...||.:|.:||         ...|.|:...|:                |
Worm    65 LFHEFCQATNSQYHQCCQFLTKVEEYE---------TSDDDGQSRRDL----------------A 104

  Fly   131 ETQEELLLNSSNANPTETAETEH--CNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDAT 193
            .:...||.:....||:.:.:.:.  |                    |.::.:.:.|.....|.||
Worm   105 SSIVSLLHSKPEDNPSGSQDEQEFWC--------------------SFLSDEVISTCITTADSAT 149

  Fly   194 GNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLN 258
                               |||..:
Worm   150 -------------------HDDEPR---------------------------------------- 155

  Fly   259 SGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEV 323
               .|||.:.......:|...||:||..||||||:|||||||.:|:...|||:||||||||||||
Worm   156 ---SDIFTEPYRLTCQYLTDAPFKEFAESMYFHRFLQWKWLEKRPVDKHTFRLYRVLGKGGFGEV 217

  Fly   324 CACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTI 388
            |||||||:|||||.|||||||:|||..|::.|.||||||:|||||||:||||||||||||||||:
Worm   218 CACQVRASGKMYALKKLEKKRVKKRHAETLSLNEKQILQRINSPFVVSLAYAYETKDALCLVLTL 282

  Fly   389 MNGGDLKFHIYN-MGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRIS 452
            |||||||||:|| |.|  ||:.:|.:|||||:..||||||.:.|:|||.|||||||||.||||||
Worm   283 MNGGDLKFHLYNLMPG--GFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRIS 345

  Fly   453 DLGLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVK 517
            ||||||||.:.|.::||||||||||||::.||:|::..||:..|||:||||||:||||.||||||
Worm   346 DLGLAVEIKDNEPIKGRVGTVGYMAPEIVKNERYSYGVDWWGVGCLIYEMIEGKAPFRQRKEKVK 410

  Fly   518 REEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRN-GRM--GGQDVMAHPFFHSTQ- 578
            ||||:|||:||.||||.||::.|:::|:.||.|....|||||. ||.  |.:::.|||||::..
Worm   411 REEVERRVREDQEKYSEKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFFNTADT 475

  Fly   579 ------LNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSI 637
                  :.|:::|||.:.|||.|||.|||||||||||||||||||.:|.:||.||.|||||.|||
Worm   476 VTGREPVPWKKMEAGKVTPPFCPDPRAVYAKDVLDIEQFSTVKGVRLDATDTQFYGKFNTGCVSI 540

  Fly   638 SWQNEMMETECFRELNVFGPEECPTPDLQINAAPE----------PDKAGCFP--FRRKKKQPAR 690
            .||:||:|||||.|||.|..|:   .::..|..|:          ..|.|.|.  ||:|.
Worm   541 PWQSEMIETECFAELNTFHDED---GNVMWNLRPDGINMDERRNGTSKPGFFSRLFRKKN----- 597

  Fly   691 TQPIPIPEHLLTTSH 705
               |.:.:.|...||
Worm   598 ---IEVTKSLHDLSH 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	25/75 (33%)
		RGS	<248..305	CDD:295367	22/56 (39%)
		STKc_GRK4_like	308..597	CDD:270756	200/299 (67%)
		S_TKc	309..574	CDD:214567	189/268 (71%)
grk-1	NP_509676.1	RGS	34..196	CDD:295367	61/268 (23%)
		PKc_like	202..500	CDD:304357	200/299 (67%)
		S_TKc	203..470	CDD:214567	189/268 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159017
Domainoid	1	1.000	385	1.000	Domainoid score	I427
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3879
Inparanoid	1	1.050	657	1.000	Inparanoid score	I406
Isobase	1	0.950	-	0	Normalized mean entropy	S1218
OMA	1	1.010	-	-		QHG47927
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	1	1.000	-	-		oto17700
orthoMCL	1	0.900	-	-		OOG6_102122
Panther	1	1.100	-	-	LDO	PTHR24355
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4592
SonicParanoid	1	1.000	-	-		X940
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750