DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and grk-2

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_497235.2	Gene:	grk-2 / 175223	WormBaseID:	WBGene00001709	Length:	707	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	160/392 - (40%)
Similarity:	234/392 - (59%)	Gaps:	17/392 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 DIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEA-QPITYKTFRMYRVLGKGGFGEVCAC 326
            |:|.:.|..:...|.|:.|:.|..|..|.|:.|||.||. ..:|...|.::|::|:||||||..|
Worm   144 DLFHRYVLEICDQLRGDIFQRFLESDKFTRFCQWKNLELNMQLTMNDFSVHRIIGRGGFGEVYGC 208

  Fly   327 QVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINS----PFVVNLAYAYETKDALCLVLT 387
            :...||||||.|.|:|||||.::||::.|.|:.:|..:::    ||:|.:.||:::.|.||.:|.
Worm   209 RKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILD 273

  Fly   388 IMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRIS 452
            :||||||.:|:...|   .|..:...|||:||..||:|:|.:.:||||.||.|||||::||||:|
Worm   274 LMNGGDLHYHLSQHG---VFTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVRVS 335

  Fly   453 DLGLAVEIPEGEMVRGRVGTVGYMAPEVI-DNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKV 516
            |||||.:..: :.....|||.|||||||: ....|..|.||||.||:||::::|.:|||..|.|.
Worm   336 DLGLACDYSK-KKPHASVGTHGYMAPEVLAKGVAYDSSADWFSLGCMLYKLLKGHSPFRQHKSKD 399

  Fly   517 KREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNW 581
            |.|.....:.:|.|..:...:.:.:.:.:.||.:.:..|||||.  .|..:|..||||  ..::|
Worm   400 KNEIDKMTLTQDIELPNEGLSKDCRDLLEGLLKRDVPDRLGCRG--KGPTEVKEHPFF--KDVDW 460

  Fly   582 RRLEAGMLEPPFVPDPHAVYAKDVLDIEQF--STVKGVNIDESDTNFYTKFNTGSVSISWQNEMM 644
            :.:....:.||.:|....|.|.|..||..|  ..||||.:.:.|::.|..||. .:|..||||:.
Worm   461 QTVYLRRMTPPLIPPRGEVNAADAFDIGNFDDDEVKGVKLQDGDSDLYKNFNI-VISERWQNEIA 524

  Fly   645 ET 646
            ||
Worm   525 ET 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	15/42 (36%)
		STKc_GRK4_like	308..597	CDD:270756	123/293 (42%)
		S_TKc	309..574	CDD:214567	117/269 (43%)
grk-2	NP_497235.2	RGS_GRK2_GRK3	30..186	CDD:188701	15/41 (37%)
		Pkinase	191..455	CDD:278497	117/269 (43%)
		STKc_beta_ARK	196..475	CDD:270757	120/286 (42%)
		S_TK_X	456..530	CDD:214529	25/72 (35%)
		PH_GRK2_subgroup	553..676	CDD:269946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820