DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and Sgk3

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001362972.1	Gene:	Sgk3 / 171498	RGDID:	620242	Length:	496	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	119/308 - (38%)
Similarity:	166/308 - (53%)	Gaps:	19/308 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQK-INSPFVVNL 372
            |...:|:|||.||:|...:.:..||.||.|.|:||.:..||.:..::.|:.:|.| :..||:|.|
  Rat   162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGL 226

  Fly   373 AYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCK 437
            .|:::|.:.|..||..:|||:|.||:..   |..|...||||||||:|..|.:||...|||||.|
  Rat   227 HYSFQTTEKLYFVLDFVNGGELFFHLQR---ERSFPEPRARFYAAEIASALGYLHSIKIVYRDLK 288

  Fly   438 PENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYE 501
            |||||||..|||.::|.||..| |...:......||..|:|||||..:.|..:.||:..|.:|||
  Rat   289 PENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYE 353

  Fly   502 MIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQ 566
            |:.|..||..|..    .|:...:...|.......:..|.|:.::||.|:.:.|||.:...:
  Rat   354 MLYGLPPFYCRDV----AEMYDNILHKPLNLRPGVSLTAWSILEELLEKNRQNRLGAKEDFL--- 411

  Fly   567 DVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTV 614
            ::..||||.|  |:|..|....:.|||.|:   |...|  ||..|..|
  Rat   412 EIQNHPFFES--LSWTDLVQKKIPPPFNPN---VAGPD--DIRNFDAV 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367
		STKc_GRK4_like	308..597	CDD:270756	113/289 (39%)
		S_TKc	309..574	CDD:214567	103/266 (39%)
Sgk3	NP_001362972.1	PX_CISK	12..120	CDD:132780
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..157
		STKc_SGK3	165..490	CDD:270755	118/305 (39%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910