Protein Alignment Gprk2 and Grk4

DIOPT Version :9

• Sequence 1: NP_001263143.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_062370.2
• Gene: Grk4 / 14772
• MGIID: 95801
• Length: 574
• Species: Mus musculus
• Alignment Length: 653
• Identity: 317/653 - (48%)
• Similarity: 403/653 - (61%)
• Gaps: 128/653 - (19%)

  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            |||||.|||.:.||||. |.:...|:|||||::|:||.:|.|..|:..::..:..:.|:|||||.
Mouse     1 MELENFVANNLLLKARL-GFNKQTGRSKKWRELLKFPPVSMCTELRWSIEKDFSSLCDKQPIGRL 64

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            |||.||:.| |...|.|.|||.|.:||:.....:...|..|..||...:::
Mouse    65 LFRQFCDTK-PDLKRCIEFLDAVAEYEVTIEEEQREFGLAIFSRFFKEKSE-------------- 114

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195
                                                                             
Mouse   115 ----------------------------------------------------------------- 114

  Fly   196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSG 260
                                               ||:...|.::|.:       .:...|.||.
Mouse   115 -----------------------------------VPLPEIPPDIVKE-------CKWNLKQNSP 137

  Fly   261 GKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCA 325
            .:::|.:|...|..:|:..||.|::.|.||:|:|||||||.:|:|..|||.||||||||||||||
Mouse   138 SQNVFEECAGIVCKYLSETPFEEYQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCA 202

  Fly   326 CQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMN 390
            ||||||||||||||||||||||||||:|.|.||:||:|::|.|||:|||.|||||||||||||||
Mouse   203 CQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMN 267

  Fly   391 GGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLG 455
            |||||:||||: |:||||..||.|||||:.|||:.|.::.|||||.||||||||||||:||||||
Mouse   268 GGDLKYHIYNL-GDPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLG 331

  Fly   456 LAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREE 520
            ||:|:|||||||||||||||||||:|::|||.|||||:..|||:||||.|.:|||..||||.|||
Mouse   332 LAMEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREE 396

  Fly   521 VDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLE 585
            ::||||.:.|:||.:|:::|||:|..||.|...:||||:  |.|...|..||.|  ..:|:.|||
Mouse   397 LERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQ--RDGVSAVKQHPIF--KDINFSRLE 457

  Fly   586 AGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECFR 650
            |.||:|||:|||.|:|.:::|||.|||.|||||:|.:|..||.:|.||||:|.|||||:|:.||:
Mouse   458 ANMLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTNDEIFYAEFATGSVTIPWQNEMIESGCFK 522

  Fly   651 ELN 653
            :||
Mouse   523 DLN 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	29/75 (39%)
		RGS	<248..305	CDD:295367	22/56 (39%)
		STKc_GRK4_like	308..597	CDD:270756	205/288 (71%)
		S_TKc	309..574	CDD:214567	192/264 (73%)
Grk4	NP_062370.2	N-terminal	1..153		60/274 (22%)
		RGS	51..183	CDD:295367	51/253 (20%)
		STKc_GRK4_like	185..469	CDD:270756	205/288 (71%)
		S_TKc	186..448	CDD:214567	192/264 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845435
Domainoid	1	1.000	418	1.000	Domainoid score	I647
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	696	1.000	Inparanoid score	I676
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47927
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	1	1.000	-	-		otm44358
orthoMCL	1	0.900	-	-		OOG6_102122
Panther	1	1.100	-	-	LDO	PTHR24355
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4592
SonicParanoid	1	1.000	-	-		X940
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790