Protein Alignment Gprk2 and GRK7

DIOPT Version :9

• Sequence 1: NP_001263143.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_631948.1
• Gene: GRK7 / 131890
• HGNCID: 17031
• Length: 553
• Species: Homo sapiens
• Alignment Length: 657
• Identity: 253/657 - (38%)
• Similarity: 360/657 - (54%)
• Gaps: 138/657 - (21%)

  Fly     3 LENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRELF 67
            |:|::|||.||:||: .||.:..:.::.|:.|..|.:..|..|:.||.:::..:.:||||||.||
Human     7 LDNLIANTAYLQARK-PSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLF 70

  Fly    68 RLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDAET 132
            |.|.... |.:.:..|||::|..:|:
Human    71 RDFLATV-PTFRKAATFLEDVQNWEL--------------------------------------- 95

  Fly   133 QEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGNGS 197
                    :...||:.:..:....|.|:                             ..|.||..
Human    96 --------AEEGPTKDSALQGLVATCAS-----------------------------APAPGNPQ 123

  Fly   198 SHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSGGK 262
            ...... .:.|||....:.|:
Human   124 PFLSQA-VATKCQAATTEEER-------------------------------------------- 143

  Fly   263 DIFAQCVNAVK----AFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEV 323
               ...|...|    |||..:||::|.:|.::.::||||..|.||::.|.|..:|||||||||||
Human   144 ---VAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEV 205

  Fly   324 CACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTI 388
            ||.||:.||||||||||:|||:||:.||.|.|:||:||:|::|||:|:||||:|:|..||||:::
Human   206 CAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSL 270

  Fly   389 MNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISD 453
            ||||||||||||:|.. |.::.|..||:|::|||:.|||:.||||||.||||:||||.|:.|:||
Human   271 MNGGDLKFHIYNVGTR-GLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSD 334

  Fly   454 LGLAVEIPEGEMVRGRVGTVGYMAPEVI-DNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVK 517
            ||||||:..|:.:..|.||.||||||:: :...|::..|||:.||.:|||:.|:.||:..||||.
Human   335 LGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVS 399

  Fly   518 REEVDRRVKEDPEKYS-SKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNW 581
            :|::.:|..:|..|:. ..|.:|||.:|:..|||..:||||.|.   ...|...|.||.:  :|:
Human   400 KEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSRE---KSDDPRKHHFFKT--INF 459

  Fly   582 RRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMET 646
            .|||||::||||||||..|||||:.:|:.||.|:||..|:.|..|:..|.||:|.|:||.|::||
Human   460 PRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIET 524

  Fly   647 ECFRELN 653
            ..|.|||
Human   525 GLFEELN 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	21/75 (28%)
		RGS	<248..305	CDD:295367	16/60 (27%)
		STKc_GRK4_like	308..597	CDD:270756	161/290 (56%)
		S_TKc	309..574	CDD:214567	147/266 (55%)
GRK7	NP_631948.1	RGS_GRK7	40..181	CDD:188703	45/265 (17%)
		STKc_GRK7	188..474	CDD:270758	161/291 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1218
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.970