DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and AgaP_AGAP012026

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_320502.4	Gene:	AgaP_AGAP012026 / 1280643	VectorBaseID:	AGAP012026	Length:	605	Species:	Anopheles gambiae

Alignment Length:	506	Identity:	190/506 - (37%)
Similarity:	270/506 - (53%)	Gaps:	70/506 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 ESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVL------NDDLIAQVRNKL--NSGG 261
            |..:|   ||:..|.....            |.:.::.::|      :.:.:|.|:..|  |...
Mosquito     5 EKTEC---HDERRKQARDI------------YDNYIMKEMLSHTHEYSKEAVAHVQKYLMKNEVP 54

  Fly   262 KDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQ-PITYKTFRMYRVLGKGGFGEVCA 325
            .::|...:..:...|.|||||:|..|..:.|:.|||.||.. .:|...|.::|::|:||||||..
Mosquito    55 VNLFEPYIEEIFHHLRGEPFRKFLESDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYG 119

  Fly   326 CQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINS----PFVVNLAYAYETKDALCLVL 386
            |:...||||||.|.|:|||||.::||::.|.|:.:|..:::    ||:|.:.||:.|.|.||.:|
Mosquito   120 CRKADTGKMYAMKCLDKKRIKMKQGETLALNERTMLSLVSTGVDCPFIVCMTYAFHTPDKLCFIL 184

  Fly   387 TIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRI 451
            .:||||||.:|:...|   .|.....:||||||..||:|:||:.|||||.||.|||||::|||||
Mosquito   185 DLMNGGDLHYHLSQHG---VFNESDMKFYAAEVILGLEHMHKRFIVYRDLKPANILLDENGHVRI 246

  Fly   452 SDLGLAVEIPEGEMVRGRVGTVGYMAPEVID-NEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEK 515
            ||||||.:..: :.....|||.|||||||:. ...|..|.|||||||:||::::|.:|||..|.|
Mosquito   247 SDLGLACDFSK-KKPHASVGTHGYMAPEVLSKGTPYDSSADWFSFGCMLYKLLKGHSPFRQHKTK 310

  Fly   516 VKREEVDRRV----KEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHS 576
            .| .|:||..    .|.||.:|.:..|    :.:.||.:.|.:||||:.|  |.::|..||||
Mosquito   311 DK-HEIDRMTLTMNVELPESFSKELRD----LLEGLLQRDIDKRLGCKGG--GAEEVKCHPFF-- 366

  Fly   577 TQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQF--STVKGVNIDESDTNFYTKFNTGSVSISW 639
            ..::|.::......||.:|....|.|.|..||..|  ...||:.:.|.|...|..|.. ::|..|
Mosquito   367 AGIDWNQVYYQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTEQDQELYRYFPL-TISERW 430

  Fly   640 QNEMMETECFRELNVFGPEECPTPDLQINAAPEPDKAGCFPFRRKKKQPAR 690
            |.|:.|| .|..:|.                 |.||   ...:||.||..|
Mosquito   431 QQEVAET-VFETVNT-----------------EADK---LEQKRKAKQKQR 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	19/59 (32%)
		STKc_GRK4_like	308..597	CDD:270756	135/297 (45%)
		S_TKc	309..574	CDD:214567	129/273 (47%)
AgaP_AGAP012026	XP_320502.4	RGS	<1..98	CDD:295367	26/107 (24%)
		PKc_like	97..443	CDD:304357	155/360 (43%)
		Pkinase	103..366	CDD:278497	129/273 (47%)
		PH_GRK2_subgroup	464..587	CDD:269946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820