DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and AgaP_AGAP004117

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_312995.5	Gene:	AgaP_AGAP004117 / 1273941	VectorBaseID:	AGAP004117	Length:	697	Species:	Anopheles gambiae

Alignment Length:	757	Identity:	492/757 - (64%)
Similarity:	552/757 - (72%)	Gaps:	116/757 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELENIVANTVYLKARE---------------------GGSDS------------NKGKSKKWRK 32
            |||||||||||||||||                     ||.:.            ||||||||||
Mosquito     1 MELENIVANTVYLKAREVWGGFFTSRADLEDSCDQGRDGGEERIKYDFLSCLCAVNKGKSKKWRK 65

  Fly    33 ILQFPHISQCINLKDKLDISYGYVIDQQPIGRELFRLFCENKRPVYFRYITFLDEVVKYEIEYIS 97
            |||||||||||:||:|:|:|||||:|||||||||||.||:.|||.|.|||||||:..:|||....
Mosquito    66 ILQFPHISQCIDLKNKIDVSYGYVVDQQPIGRELFRQFCKVKRPQYSRYITFLDDATRYEIAADE 130

  Fly    98 NRIFIGHDIGRRFLDV--EAQLELRNGSGGDALDAETQEELLLNSSNANPTETAETEHCNNTTAN 160
            :|:.:..::.:|:|.:  |:|.|...|.||                            | ::...
Mosquito   131 HRVDLAFEVAKRYLGLCTESQREDSGGGGG----------------------------C-DSDGG 166

  Fly   161 NCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGG 225
            .|                           ||.:|.|      ||  .|....|||.||  ...|.
Mosquito   167 KC---------------------------DDDSGIG------GD--TKKLSNHDDPEK--SLTGS 194

  Fly   226 GGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSGGKDIFAQCVNAVKAFLAGEPFREFESSMYF 290
            .......:....||.||||||||::.|:|.||::|.|::|...:.||:||||||||||||:||||
Mosquito   195 NSVTTNTINNEKDEFVLDVLNDDMVGQIRTKLSTGSKELFEASITAVRAFLAGEPFREFEASMYF 259

  Fly   291 HRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCACQ-------------VRATGKMYACKKLEK 342
            |||||||||||||:|||||||||||||||||||||||             |||||||||||||||
Mosquito   260 HRYLQWKWLEAQPVTYKTFRMYRVLGKGGFGEVCACQVGVAGSRKLERAAVRATGKMYACKKLEK 324

  Fly   343 KRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGF 407
            ||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||
Mosquito   325 KRIKKRKGESMVLIEKQILQKINSRFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGF 389

  Fly   408 ELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMVRGRVGT 472
            ||.|||||||||.|||:|||:||||||||||||||||||||||||||||||||||||||||||||
Mosquito   390 ELSRARFYAAEVVCGLEHLHQQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMVRGRVGT 454

  Fly   473 VGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFN 537
            ||||||||||||||:|||||||||||||||||||||||.|||||||||||||||||.||||.||:
Mosquito   455 VGYMAPEVIDNEKYSFSPDWFSFGCLLYEMIEGQAPFRARKEKVKREEVDRRVKEDAEKYSHKFS 519

  Fly   538 DEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYA 602
            |:|||:|||||.|::|.||||||||.|.::|..:|||:|  :||:|||||:.:||||||||||||
Mosquito   520 DDAKSLCQQLLVKAVKSRLGCRNGRHGAREVKLNPFFNS--INWKRLEAGLNDPPFVPDPHAVYA 582

  Fly   603 KDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECFRELNVFGPEECPTPDLQI 667
            ||||||||||||||||:|.:|.|||||||||||||.||:||:||||||||||||..|||||||.:
Mosquito   583 KDVLDIEQFSTVKGVNLDATDENFYTKFNTGSVSIPWQDEMIETECFRELNVFGANECPTPDLLV 647

  Fly   668 NAAPEPDKAGCFPFRRKKKQPARTQPIPIPEHLLTTSHSVSS 709
            ||.|..:|.|||||||||||..|.:|:|..|.||::|.:..|
Mosquito   648 NAPPVVEKPGCFPFRRKKKQTPREKPVPFNEKLLSSSQTTVS 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	47/75 (63%)
		RGS	<248..305	CDD:295367	39/56 (70%)
		STKc_GRK4_like	308..597	CDD:270756	257/301 (85%)
		S_TKc	309..574	CDD:214567	241/277 (87%)
AgaP_AGAP004117	XP_312995.5	RGS	86..274	CDD:295367	103/253 (41%)
		STKc_GRK4_like	277..577	CDD:270756	257/301 (85%)
		S_TKc	278..556	CDD:214567	241/277 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	485	1.000	Domainoid score	I1342
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3879
Inparanoid	1	1.050	840	1.000	Inparanoid score	I1316
OMA	1	1.010	-	-		QHG47927
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	1	1.000	-	-		oto111578
Panther	1	1.100	-	-	LDO	PTHR24355
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X940
TreeFam	1	0.960	-	-
	13	12.940