DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and Rps6ka3

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_683747.1	Gene:	Rps6ka3 / 110651	MGIID:	104557	Length:	740	Species:	Mus musculus

Alignment Length:	292	Identity:	108/292 - (36%)
Similarity:	165/292 - (56%)	Gaps:	18/292 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 FRMYRVLGKGGFGEVCACQVRATG----KMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFV 369
            |.:.:|||:|.||:|...: :.:|    ::||.|.|:|..:|.| ......:|:.||.::|.||:
Mouse    68 FELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVR-DRVRTKMERDILVEVNHPFI 130

  Fly   370 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYR 434
            |.|.||::|:..|.|:|..:.||||   ...:..|..|..|..:||.||:|..|.|||..||:||
Mouse   131 VKLHYAFQTEGKLYLILDFLRGGDL---FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYR 192

  Fly   435 DCKPENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCL 498
            |.||||||||:.||::::|.||:.| |...:......|||.||||||::...:..|.||:|||.|
Mouse   193 DLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVL 257

  Fly   499 LYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRM 563
            ::||:.|..||:.:..|.....:.:.....|:..|    .||:|:.:.|..::...|||.  |..
Mouse   258 MFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLS----PEAQSLLRMLFKRNPANRLGA--GPD 316

  Fly   564 GGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVP 595
            |.:::..|.||  :.::|.:|....:.|||.|
Mouse   317 GVEEIKRHSFF--STIDWNKLYRREIHPPFKP 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367
		STKc_GRK4_like	308..597	CDD:270756	108/292 (37%)
		S_TKc	309..574	CDD:214567	100/269 (37%)
Rps6ka3	NP_683747.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		STKc_RSK_N	72..388	CDD:270734	107/288 (37%)
		STKc_RSK2_C	402..740	CDD:271078
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910