DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gprk2 and Grk2

DIOPT Version :9

Sequence 1:NP_001263143.1 Gene:Gprk2 / 49045 FlyBaseID:FBgn0261988 Length:714 Species:Drosophila melanogaster
Sequence 2:NP_001277747.1 Gene:Grk2 / 110355 MGIID:87940 Length:689 Species:Mus musculus


Alignment Length:658 Identity:208/658 - (31%)
Similarity:310/658 - (47%) Gaps:149/658 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCIN--LKDKLDISYGYVIDQQPIGR 64
            :||.::|:..||.|.|....:...::.| :.:|..|.|...:.  |:|:.::::..:..|: :|.
Mouse     3 DLEAVLADVSYLMAMEKSKATPAARASK-KILLPEPSIRSVMQKYLEDRGEVTFEKIFSQK-LGY 65

  Fly    65 ELFRLFC----ENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGG 125
            .|||.||    |..:|:    :.|.:|:.|||                 .|:.|.:..:|:   .
Mouse    66 LLFRDFCLNHLEEAKPL----VEFYEEIKKYE-----------------KLETEEERVVRS---R 106

  Fly   126 DALDAETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGD 190
            :..|:...:|||..|   :|.....|||.                                    
Mouse   107 EIFDSYIMKELLACS---HPFSKNATEHV------------------------------------ 132

  Fly   191 DATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRN 255
                                :||  ..|          |.||                       
Mouse   133 --------------------QGH--LVK----------KQVP----------------------- 142

  Fly   256 KLNSGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQ-PITYKTFRMYRVLGKGG 319
                  .|:|...:..:...|.|:.|::|..|..|.|:.|||.:|.. .:|...|.::|::|:||
Mouse   143 ------PDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGG 201

  Fly   320 FGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINS---PFVVNLAYAYETKDA 381
            ||||..|:...||||||.|.|:|||||.::||::.|.|:.:|..:::   ||:|.::||:.|.|.
Mouse   202 FGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDK 266

  Fly   382 LCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDH 446
            |..:|.:||||||.:|:...|   .|.....||||||:..||:|:|.:.:||||.||.|||||:|
Mouse   267 LSFILDLMNGGDLHYHLSQHG---VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEH 328

  Fly   447 GHVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVID-NEKYAFSPDWFSFGCLLYEMIEGQAPFR 510
            |||||||||||.:..: :.....|||.|||||||:. ...|..|.||||.||:|::::.|.:|||
Mouse   329 GHVRISDLGLACDFSK-KRPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392

  Fly   511 MRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFH 575
            ..|.|.| .|:||.......:....|:.|.:|:.:.||.:.:.:||||. || |.|:|...|||.
Mouse   393 QHKTKDK-HEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCL-GR-GAQEVKESPFFR 454

  Fly   576 STQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQF--STVKGVNIDESDTNFYTKFNTGSVSIS 638
            |  |:|:.:......||.:|....|.|.|..||..|  ...||:.:.:||...|..|.. ::|..
Mouse   455 S--LDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISER 516

  Fly   639 WQNEMMET 646
            ||.|:.||
Mouse   517 WQQEVAET 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk2NP_001263143.1 RGS 35..>111 CDD:295367 18/81 (22%)
RGS <248..305 CDD:295367 13/57 (23%)
STKc_GRK4_like 308..597 CDD:270756 131/292 (45%)
S_TKc 309..574 CDD:214567 123/268 (46%)
Grk2NP_001277747.1 N-terminal 1..190 59/312 (19%)
RGS_GRK2_GRK3 30..186 CDD:188701 51/281 (18%)
STKc_GRK2 190..510 CDD:271125 142/328 (43%)
Pkinase 191..453 CDD:278497 123/268 (46%)
PH_GRK2_subgroup 553..670 CDD:269946
PH 562..650 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845433
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0986
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1104340at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.750

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