DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and SGK2

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001186193.1	Gene:	SGK2 / 10110	HGNCID:	13900	Length:	367	Species:	Homo sapiens

Alignment Length:	298	Identity:	114/298 - (38%)
Similarity:	162/298 - (54%)	Gaps:	17/298 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 AQPITYKTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQK-I 364
            |||   ..|...:|:|||.:|:|...:.::.|..||.|.|:||.|.|:|.:|.::.|:.:|.| :
Human    30 AQP---TDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNV 91

  Fly   365 NSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQ 429
            ..||:|.|.|:::|.:.|..||..:|||:|.||:..   |..|...||||||||||..:.:||..
Human    92 RHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQR---ERRFLEPRARFYAAEVASAIGYLHSL 153

  Fly   430 GIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMVRGR-VGTVGYMAPEVIDNEKYAFSPDWF 493
            .|:|||.||||||||..|||.::|.||..|..|.|..... .||..|:||||:..|.|..:.||:
Human   154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWW 218

  Fly   494 SFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGC 558
            ..|.:||||:.|..||..:..    .::...:...|.:........|..:.|.||.|..:||||.
Human   219 CLGAVLYEMLHGLPPFYSQDV----SQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGS 279

  Fly   559 RNGRMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVPD 596
            :...:   ::..|.||  :.:||..|....|.|||.|:
Human   280 KADFL---EIKNHVFF--SPINWDDLYHKRLTPPFNPN 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	3/3 (100%)
		STKc_GRK4_like	308..597	CDD:270756	111/291 (38%)
		S_TKc	309..574	CDD:214567	101/266 (38%)
SGK2	NP_001186193.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		STKc_SGK2	39..359	CDD:270754	110/286 (38%)
		Nuclear localization signal. /evidence=ECO:0000250	68..78		5/9 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910