Protein Alignment Gprk2 and grk6

DIOPT Version :10

• Sequence 1: NP_476867.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: XP_002936988.1
• Gene: grk6 / 100379796
• XenbaseID: XB-GENE-1004800
• Length: 575
• Species: Xenopus tropicalis
• Alignment Length: 702
• Identity: 346/702 - (49%)
• Similarity: 433/702 - (61%)
• Gaps: 140/702 - (19%)

  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            |||||||||||.|||||||..:.||||||||::|||||||.|..|:..|:..|..:.|:|||||.
 Frog     1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISDCEELRRSLERDYHSLCDRQPIGRL 65

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            |||.|||. ||...|.:.|||.|.:||:.....|...|..:..::|...::         |.: .
 Frog    66 LFRQFCET-RPELLRCVRFLDAVAEYEVSPDEKRKECGQQLIEKYLTATSE---------DYI-T 119

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195
            |..|.::|:.     ||:.|...|
 Frog   120 EVPEHMVLSC-----TESLEINPC----------------------------------------- 138

  Fly   196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSG 260
                                                                             
 Frog   139 ----------------------------------------------------------------- 138

  Fly   261 GKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCA 325
             |::|.:....|..||:..||.::..|:|::|:||||.||.||:|..|||.||||||||||||||
 Frog   139 -KELFKEPSKLVHDFLSMAPFSDYLDSLYYNRFLQWKCLERQPVTKNTFRQYRVLGKGGFGEVCA 202

  Fly   326 CQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMN 390
            ||||||||||||||||||||||||||||.|.|||||:::||.|||:||||||||||||||||:||
 Frog   203 CQVRATGKMYACKKLEKKRIKKRKGESMALNEKQILERVNSRFVVSLAYAYETKDALCLVLTLMN 267

  Fly   391 GGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLG 455
            |||||||||:| |:.||:..||.|||||:.|||:|||::.|||||.|||||||||.||:||||||
 Frog   268 GGDLKFHIYHM-GDAGFDEGRAIFYAAEICCGLEHLHQERIVYRDLKPENILLDDDGHIRISDLG 331

  Fly   456 LAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREE 520
            |||.|||.:.::|||||||||||||:.||:|.|||||::.|||||||||||:||:.||.|:||||
 Frog   332 LAVHIPEDQTIKGRVGTVGYMAPEVVRNERYTFSPDWWALGCLLYEMIEGQSPFQQRKRKIKREE 396

  Fly   521 VDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLE 585
            |:|.|||..|:||:||:.:|:|:|:.||.|...:|||| :|| |.|:|..||.|  .|:|::|||
 Frog   397 VERLVKEGQEEYSAKFSPDAQSLCKMLLLKDPSERLGC-HGR-GAQEVKEHPLF--KQINFKRLE 457

  Fly   586 AGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECFR 650
            ||:|||||.|||.|:|.|||||||||||||||:::::|.:||.||.||::.|.|||||::|:||.
 Frog   458 AGILEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEQTDNDFYRKFATGNICIPWQNEMVDTDCFW 522

  Fly   651 ELNVFGPEECPTPDLQINAAPEPD-KAGCFP--FRRK---------KKQPAR 690
            ||:....:....|||.....|.|. |.|...  |.|:         :::|.|
 Frog   523 ELSALPTDGSIPPDLDWRGLPSPQPKKGLLQRFFSRQDCCGNCSDSEEEPTR 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_476867.1	RGS	35..>111	CDD:470619	33/75 (44%)
		RGS	<248..305	CDD:470619	18/56 (32%)
		STKc_GRK4_like	308..597	CDD:270756	210/288 (73%)
		S_TK_X	578..642	CDD:214529	42/63 (67%)
grk6	XP_002936988.1	RGS	35..179	CDD:470619	58/266 (22%)
		STKc_GRK6	185..469	CDD:270779	210/288 (73%)