DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and prkcg

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_001921715.1	Gene:	prkcg / 100003514	ZFINID:	ZDB-GENE-090206-1	Length:	695	Species:	Danio rerio

Alignment Length:	364	Identity:	124/364 - (34%)
Similarity:	195/364 - (53%)	Gaps:	44/364 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSP-FVVNL 372
            |....|||||.||:|...:.:.:.:::|.|.|:|..:.:.:.....::|:::|.....| |:.:|
Zfish   363 FNFLMVLGKGSFGKVLLAEEKGSERLFAIKMLKKDVLFQDEDTESAMVERRVLALSGRPHFLTSL 427

  Fly   373 AYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCK 437
            ..|::|:|.|..|:..:|||||.|||..:|   .|:...|.|||||:|.||..||.:||:|||.|
Zfish   428 YCAFQTEDRLYYVMEYVNGGDLMFHIQIVG---KFKEPHAAFYAAEIAVGLFFLHNKGIIYRDLK 489

  Fly   438 PENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYE 501
            .:|:|||..||::|:|.|:..| :.||:..|...||..|:|||::..:.|..:.||:|:|.||||
Zfish   490 LDNVLLDSEGHIKIADFGMCREGMMEGDTTRTFCGTPDYIAPEIVAYQPYGKAVDWWSYGVLLYE 554

  Fly   502 MIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQ 566
            |:.||.||    :.:..||:.:.:.|....|....:.||.::|:.||.|:..:|||      ||:
Zfish   555 MLAGQPPF----DGIDEEELFQSIMEQSVSYPKSLSREAVAICKGLLTKNPAKRLG------GGE 609

  Fly   567 D----VMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFY 627
            |    :..||||.  .::|.|||...::|||.|              :....||.|.|:    |:
Zfish   610 DAERELREHPFFR--WIDWDRLERLEIQPPFKP--------------RSGGKKGENFDK----FF 654

  Fly   628 TKFNTGSVSISWQNEMM---ETECFRELNVFGPEECPTP 663
            |  :|.|.......:::   ..|.|::......|..|:|
Zfish   655 T--STSSALTPSDPDVLAAINQEEFQDFTFMNSEFPPSP 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367
		STKc_GRK4_like	308..597	CDD:270756	111/293 (38%)
		S_TKc	309..574	CDD:214567	101/270 (37%)
prkcg	XP_001921715.1	C1_1	56..108	CDD:278556
		C1_1	121..173	CDD:278556
		C2_PKC_alpha_gamma	178..308	CDD:175992
		S_TKc	363..621	CDD:214567	101/270 (37%)
		STKc_cPKC	366..684	CDD:270739	120/352 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910