DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment boca and Mesd

DIOPT Version :9

Sequence 1:	NP_724578.1	Gene:	boca / 48986	FlyBaseID:	FBgn0004132	Length:	180	Species:	Drosophila melanogaster
Sequence 2:	NP_075892.3	Gene:	Mesd / 67943	MGIID:	1891421	Length:	224	Species:	Mus musculus

Alignment Length:	177	Identity:	86/177 - (48%)
Similarity:	122/177 - (68%)	Gaps:	9/177 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RLVLLLLALTPLVL--------AKKFKEEEKPAWAKKDIRDYSEADLERLLDQWEEDEEPLEDDE 60
            |.|||.|..:.|:|        |....|...|...|||||||::||:.|||:|||:|:: :|:.:
Mouse     8 RAVLLFLCASDLLLLPPPNAYAADTPGEATPPPRKKKDIRDYNDADMARLLEQWEKDDD-IEEGD 71

  Fly    61 LPEHLRPQPKLDLSNLDSKSPEDLLKVSKKGRTLMTFVSVTGNPTREESDTITKLWQTSLWNNHI 125
            ||||.||...:|.|.||...||.:||::|||:|||.||:|:||||.:|::.||.|||.||:|.:.
Mouse    72 LPEHKRPSAPIDFSKLDPGKPESILKMTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANY 136

  Fly   126 QAERYMVDDNRAIFLFKDGTQAWDAKDFLIEQERCKGVTIENKEYPG 172
            ..:|::|..:||||:.:||:.||:.||||:.|:||..||:|.:.|||
Mouse   137 DVQRFIVGSDRAIFMLRDGSYAWEIKDFLVSQDRCAEVTLEGQMYPG 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boca	NP_724578.1	Mesd	31..178	CDD:287194	76/142 (54%)
Mesd	NP_075892.3	Chaperone domain. /evidence=ECO:0000269\|PubMed:21397183	1..155		69/147 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..49		8/20 (40%)
		Mesd	43..192	CDD:370866	76/142 (54%)
		Escort domain. /evidence=ECO:0000269\|PubMed:21397183	156..195		15/28 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..224		3/6 (50%)
		Prevents secretion from ER	221..224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850204
Domainoid	1	1.000	172	1.000	Domainoid score	I3717
eggNOG	1	0.900	-	-		E1_KOG4357
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11347
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4043
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45813
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007230
OrthoInspector	1	1.000	-	-		oto94618
orthoMCL	1	0.900	-	-		OOG6_107397
Panther	1	1.100	-	-	LDO	PTHR17600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4085
SonicParanoid	1	1.000	-	-		X5334
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790