Protein Alignment NRDC and CG10588

DIOPT Version :9

• Sequence 1: NP_002516.2
• Gene: NRDC / 4898
• HGNCID: 7995
• Length: 1219
• Species: Homo sapiens
• Sequence 2: NP_001287135.1
• Gene: CG10588 / 40316
• FlyBaseID: FBgn0037037
• Length: 1058
• Species: Drosophila melanogaster
• Alignment Length: 1144
• Identity: 340/1144 - (29%)
• Similarity: 567/1144 - (49%)
• Gaps: 166/1144 - (14%)

Human   100 DPEIVKSPSDPKQYRYIKLQNGLQALLISDLSNMEGKTGNTTDDEEEEEVEEEEEDDDEDSGAEI 164
            :|:  ||..|.|.||.:.|.|||:|:||||
  Fly    39 EPD--KSDGDSKLYRALTLSNGLRAMLISD----------------------------------- 66

Human   165 EDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEERAEARKKTTEKQQLQSLFLLWSKLTDRLWFK 229
                  .:.||...                   .||       .::.|.|
  Fly    67 ------SYIDEPSI-------------------HRA-------SRESLNS--------------- 84

Human   230 STYSKMSSTLLVETRNLYGVVGAESRSAPVQHLAGWQAEEQQGETDTVLSAAALCVGVGSFADPD 294
                        .|.|..|                            .|:|.|:.||||||::|.
  Fly    85 ------------STENFNG----------------------------KLAACAVLVGVGSFSEPQ 109

Human   295 DLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWA 359
            ...|||||:|||:||||.|:|.||.||:|:.|.||..||.|:.|.|.|.|::.:.:....:|.:.
  Fly   110 QYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHTENEETCFYFELDQTHLDRGMDLFM 174

Human   360 QFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPR 424
            .....|||:.||:.||..||.||::.....|..|::.:..|||..|:|.|.|.|||.:|||....
  Fly   175 NLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASLASEGYPHGTFSWGNYKTLKEGVD 239

Human   425 KNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFGHLT--DP 487
            .:::  |..|.:|:..:|.|:.|.:.:|::.:||.||:.:....:.||.:.....:...|.  ..
  Fly   240 DSSL--HKELHKFYRDHYGSNRMVVALQAQLSLDELEELLVRHCADIPTSQQNSIDVSQLNYQKA 302

Human   488 FDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWAL 552
            |....:..::.|.|:..:..|.:||.|||.:..||.||..:||.|:|:||.||:.::||...|.:
  Fly   303 FRDQFYKDVFLVQPVEDVCKLELTWVLPPMKNFYRSKPDMFISQLIGYEGVGSLCAYLRHHLWCI 367

Human   553 ALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIE 617
            ::..|..|:.|:.||.||:|:|.|.|:|:|::|..||....|.::|::......:..::|.::||
  Fly   368 SVVAGVAESSFDSNSIYSLFNICIYLSDDGFDHIDEVLEATFAWVKLIINSDQLQDSYKESQQIE 432

Human   618 DNEFHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSG 682
            :|.|.:|.:..|:::|:::.|:....|.:|:|||.||.|:|:...| |.|.|.: .|.|..::..
  Fly   433 NNNFRFQIEPPPIDHVQSIVESFNYLPSKDVLTGPQLYFQYEESAI-ELLRQHM-NKFNFNIMIS 495

Human   683 A----NEGKCDLKEKWFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCP 743
            :    .:.:.|.:|.|||||:....:...|..:|..:..:. :||.|..|.::.|||.:...:..
  Fly   496 SYIPYEKNEYDQREPWFGTQFKTISMPPKWQTMWEQSATIK-ELHYPQPNPFVTTDFKIHWVESG 559

Human   744 E---TEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLA 805
            :   :..|..::......||:::||.||:|..||..:.|:||:::|....:|..:|..::...:|
  Fly   560 KPHVSRSPKALIRNDLCELWFRQDNIFKLPDGYINLYFITPLVRESVKQYMLGVLFTYLVEFRMA 624

Human   806 EPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTY 870
            |..|.|..|.|.|.|..|:.||::||.|:|.|||||.::|::.:..............:..|:..
  Fly   625 EQLYPALEAGLTYGLYIGDKGLVMRVSGYNEKLPLLVEIILNMMQTIELDIGQVNAFKDLKKRQI 689

Human   871 FNILIKPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTS 935
            :|.||..::|..|:||.|||..|:|||.||:: :|.::::.:.||.:.|..:::|:||:|||.|.
  Fly   690 YNALINGKSLNLDLRLSILENKRFSMISKYES-VDDITMDDIKSFKENFHKKMYVKGLIQGNFTE 753

Human   936 TESMDFLKYVVDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEVTVYYQSGTRSLR 1000
            .::.|.::.|:|....:.|:....:...::::|.|.:..:.|.||:.|:|:.:|.|||.|...|:
  Fly   754 DQATDLMQKVLDTYKSEKLDNLSALDNHLLQIPLGSYYLRAKTLNEDDSNTIITNYYQIGPSDLK 818

Human  1001 EYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEE 1065
            ...:|:|:.:.:|||.|:.|||::.|||.:....|...|:|.|.:|:.||.||:.::.|:::||.
  Fly   819 MECIMDLVELIVEEPFFNQLRTQEQLGYSLGIHQRIGYGVLAFLITINTQETKHRADYVEQRIEA 883

Human  1066 FLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKS 1130
            |.|...|.:..:::..|......||..|:..||.|.|||.|||:|:||::|.|:|:..:|:.|..
  Fly   884 FRSRMAELVSQMSDTEFKNIRETLINGKKLGDTSLDEEVLRNWSEIVTKEYFFNRIETQIQMLSH 948

Human  1131 FSKSDLVNWFKAHRGPGSKMLSVHVVGYGKYELEEDGTPSSEDSNSSCEVM-------------- 1181
            .:|.|::|:...:.....:.|||.||  |.:....:.|..:..|.|..:::
  Fly   949 LTKEDVLNFLNDNDKNNLRKLSVQVV--GNHNQTSNSTAQASRSGSLSDLLDDVQDNMANETDSA 1011

Human  1182 -------QLTYLPTSPLLADCIIPITDIRAFTTTLNLLP 1213
                   :|.:|..|    |....|.||.||...|.:.|
  Fly  1012 KPMTDKIRLEFLGES----DDPSSIKDIYAFKKDLYVFP 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NRDC	NP_002516.2	Ptr	279..1157	CDD:223956	298/886 (34%)
		Peptidase_M16	279..405	CDD:279066	55/125 (44%)
		Peptidase_M16_C	430..616	CDD:282978	57/187 (30%)
		Peptidase_M16_M	621..902	CDD:292805	90/287 (31%)
		Peptidase_M16_C	907..1089	CDD:282978	55/181 (30%)
CG10588	NP_001287135.1	Ptr	27..980	CDD:223956	326/1072 (30%)
		Peptidase_M16	85..214	CDD:279066	56/156 (36%)
		Peptidase_M16_C	244..419	CDD:282978	56/174 (32%)
		Peptidase_M16_M	436..720	CDD:292805	89/286 (31%)
		Peptidase_M16_C	724..907	CDD:282978	55/182 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159742
Domainoid	1	1.000	175	1.000	Domainoid score	I3649
eggNOG	1	0.900	-	-		E1_COG1025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	623	1.000	Inparanoid score	I871
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63000
OrthoDB	1	1.010	-	-		D1008844at2759
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	1	1.000	-	-		otm41748
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	1	1.100	-	-	O	PTHR43690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4190
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770