DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and MAP3K13

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001229243.1	Gene:	MAP3K13 / 9175	HGNCID:	6852	Length:	966	Species:	Homo sapiens

Alignment Length:	462	Identity:	128/462 - (27%)
Similarity:	197/462 - (42%)	Gaps:	115/462 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 RMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGT 185
            |.|:|:...|.      :||     ..|..|:|:    |.|.|..:||:       |.|.:...|
Human    53 RTELIESVHSP------VTT-----TVLTSVSED----SRDQFENSVLQ-------LREHDESET 95

  Fly   186 FLVRPSEHNPNGYSLS------VKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAY 244
            .:.:.:.:..:|.|.|      ::....|.|            :||:.
Human    96 AVSQGNSNTVDGESTSGTEDIKIQFSRSGSG------------SGGFL----------------- 131

  Fly   245 SKENALGLCHILSRPCPKPQPQMW---------DLGPELRDKYEIPRSEIQLLRKLGRGNFGEVF 300
              |...|        |.:|   :|         |...:.:|.:|:|..||..|:.||.|..|.||
Human   132 --EGLFG--------CLRP---VWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVF 183

  Fly   301 YGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSL 365
            .||:| :.:||:|.:||...:....|      :|.:|..::|...||:|.....|:.||.:.|.|
Human   184 LGKFR-AEEVAIKKVREQNETDIKHL------RKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 241

  Fly   366 LDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVI 430
            .:.||.  ||.:....|:..:|.:||||.||...::|||||.:.|||:...:..||.|||.::.:
Human   242 YEVLRA--GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL 304

  Fly   431 ADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENI- 494
            :|..  .|......|.|.|||.|.....|.|.|:||:|::|.||.| |::||..:.|..:|..:
Human   305 SDKS--TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVG 366

  Fly   495 ERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF-EFLNH---------------YFESFSVT 543
            .....:|.|:.  .||....|:.|.|.:.|..||:| :.|.|               ||:
Human   367 SNSLHLPVPST--CPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFK----- 424

  Fly   544 SEVPYRE 550
            |:..:||
Human   425 SQAEWRE 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	7/28 (25%)
		SH2_Src_family	158..259	CDD:199827	17/106 (16%)
		STYKc	285..537	CDD:214568	89/268 (33%)
		PTKc_Src_like	289..538	CDD:270630	88/265 (33%)
MAP3K13	NP_001229243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..114		4/23 (17%)
		STYKc	168..402	CDD:214568	87/247 (35%)
		STKc_MAP3K12_13	174..410	CDD:270961	87/249 (35%)
		Leucine-zipper 1	433..454
		Leucine-zipper 2	486..507
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..599
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..655
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..834
		Acidic. /evidence=ECO:0000305	815..828
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	846..908
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910