Protein Alignment Src64B and Jak1

DIOPT Version :9

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_445918.1
• Gene: Jak1 / 84598
• RGDID: 69056
• Length: 1153
• Species: Rattus norvegicus
• Alignment Length: 592
• Identity: 151/592 - (25%)
• Similarity: 246/592 - (41%)
• Gaps: 118/592 - (19%)

  Fly    32 QTHINSSGGGNMGGVLGQKHNNGGSLDSRY-----TPDPNHRGPLKIGGKGGVDIIRPRTTPTGV 91
            :|||.|      |.:|..|.:.|.:.:.:.     ..||:||           ||.........:
  Rat   593 RTHIYS------GTLLDYKDDEGIAEEKKIKVILKVLDPSHR-----------DISLAFFEAASM 640

  Fly    92 PGVVLKRVVVALYDYKSRDESDL---SFMKGDRMEVIDDTESD-----W-WRVV----------- 136
            ...|..:.:|.||....||..::   .|::|..:::....:||     | ::|.
  Rat   641 MRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLE 705

  Fly   137 ------------NLTTRQEGL--------------IPLNFVAEERSVNSEDWFFENVLRKEADKL 175
                        ||...:||:              ||::.:..:..:....|.....:....:..
  Rat   706 DKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLS 770

  Fly   176 LLAEENPRGTFLVRPSEHNPNGYSLSVKD---WEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSL 237
            :.|::...||.|   .|...|| .:.:||   .|..|.|..:...:.|         :.:....|
  Rat   771 VAADKWSFGTTL---WEICYNG-EIPLKDKTLIEKERFYESRCRPVTP---------SCKELADL 822

  Fly   238 QALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELR-----DKYEIPRSEIQLLRKLGRGNFG 297
            ....|.|. .|.......:.|...|.:.|..|:..|.:     |.....:..::.:|.||.|:||
  Rat   823 MTRCMNYD-PNQRPFFRAIMRDINKLEEQNPDIVSEKQPITEVDPTHFEKRFLKRIRDLGEGHFG 886

  Fly   298 EVFYGKWRNSID-----VAVKTLR--EGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQE--EPI 353
            :|...::....|     ||||:|:  .|....|...:|..|::...|..:|....:|.::  ..|
  Rat   887 KVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGI 951

  Fly   354 YIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNV 418
            .::.|::..|||.::|.:...: ::.:..:..|.|:..||:||.|:|.:||||||||||:...:.
  Rat   952 KLIMEFLPSGSLKEYLPKNKNK-INLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQ 1015

  Fly   419 AKICDFGLARVIADDE--YCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVP 481
            .||.||||.:.|..|:  |..|.....||.|.|||.:|..||.|.|||||:|:.|.||.||....
  Rat  1016 VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD 1080

  Fly   482 YPGM----------HSR----EVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEF 532
            :..|          |.:    .::..::.|.|:..|.|  .||.:|||:.:||:..|..|.||:.
  Rat  1081 FSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPN--CPDEVYQLMRKCWEFQPSNRTTFQN 1143

  Fly   533 LNHYFES 539
            |...||:
  Rat  1144 LIEGFEA 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	17/96 (18%)
		SH2_Src_family	158..259	CDD:199827	18/103 (17%)
		STYKc	285..537	CDD:214568	93/276 (34%)
		PTKc_Src_like	289..538	CDD:270630	93/273 (34%)
Jak1	NP_445918.1	B41	37..286	CDD:214604
		FERM_C_JAK1	282..426	CDD:275412
		SH2_Jak1	426..526	CDD:198241
		PTK_Jak1_rpt1	582..845	CDD:270662	51/282 (18%)
		Pkinase_Tyr	582..844	CDD:285015	51/281 (18%)
		PTKc_Jak1_rpt2	869..1152	CDD:173644	95/285 (33%)
		Pkinase_Tyr	874..1146	CDD:285015	93/274 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810