Protein Alignment Src64B and Src

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_114183.1
• Gene: Src / 83805
• RGDID: 620795
• Length: 542
• Species: Rattus norvegicus
• Alignment Length: 523
• Identity: 258/523 - (49%)
• Similarity: 347/523 - (66%)
• Gaps: 34/523 - (6%)

  Fly    51 HNNGGSLDSRYTPD-----PNHRG------------PLKIGGKGGVD-IIRPRTTPTGVPGVVLK 97
            |..||:..:..||.     ..|||            |...||....| :..|:.......||.
  Rat    25 HGAGGAFPASQTPSKPASADGHRGPNAAFVPPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVT-- 87

  Fly    98 RVVVALYDYKSRDESDLSFMKGDRMEVIDDT------ESDWWRVVNLTTRQEGLIPLNFVAEERS 156
             ..||||||:||.|:||||.||:|::::::|      |.|||...:|:|.|.|.||.|:||...|
  Rat    88 -TFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDS 151

  Fly   157 VNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPL 221
            :.:|:|:|..:.|:|:::|||..||||||||||.||.....|.|||.|:::.:|.:||||:|:.|
  Rat   152 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 216

  Fly   222 DNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQ 286
            |:||:||.:...|.|||.||..||| :|.||||.|:..||..:||...|.   :|.:||||..::
  Rat   217 DSGGFYITSRTQFNSLQQLVAYYSK-HADGLCHRLTTVCPTSKPQTQGLA---KDAWEIPRESLR 277

  Fly   287 LLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEE 351
            |..|||:|.||||:.|.|..:..||:|||:.||||..||||||.:|||.||.:||.||||.| ||
  Rat   278 LEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EE 341

  Fly   352 PIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGEN 416
            |||||.|||:||||||||:...|:||....|:.::.|:||||.|:|....:||||.|.|:|:|||
  Rat   342 PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGEN 406

  Fly   417 NVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVP 481
            .|.|:.||||||:|.|:||..:||::||:|||||||.:||:|:|||||||:||||.||.|.|:||
  Rat   407 LVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 471

  Fly   482 YPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEV 546
            ||||.:|||::.:|||:|||.|..  .|::::.|:.|||...||:|||||:|..:.|.:..::|.
  Rat   472 YPGMVNREVLDQVERGYRMPCPPE--CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 534

  Fly   547 PYR 549
            .|:
  Rat   535 QYQ 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	52/100 (52%)
		PTKc_Src_like	289..538	CDD:270630	146/248 (59%)
		SH3_Src_like	99..150	CDD:212779	27/56 (48%)
Src	NP_114183.1	PTKc_Src	266..542	CDD:270656	155/275 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		7/23 (30%)
		SH3_Src	88..149	CDD:212941	30/60 (50%)
		SH2_Src_Src	153..253	CDD:198228	52/100 (52%)