DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and tnni3k

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001191752.1	Gene:	tnni3k / 799621	ZFINID:	ZDB-GENE-081104-399	Length:	835	Species:	Danio rerio

Alignment Length:	364	Identity:	105/364 - (28%)
Similarity:	170/364 - (46%)	Gaps:	77/364 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 WEDGRGYH-----VKHYRIKPLDNG-----------GYYIATNQTFPSLQALVMAYSKENALGLC 253
            |...:|:.     :|||: :|.|:.           |.|::.    ||....:.:.:||.|..|.
Zfish   388 WAYEKGHDAIVTLLKHYK-RPQDDSPCNEYSQPGGDGSYVSV----PSPLGKIKSMTKEKADVLL 447

  Fly   254 HILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREG 318
                            |...|...:.:..||::....:|.|:||:|:.||.||.| ||:|..|..
Zfish   448 ----------------LRASLPSNFHLQLSELEFNEIIGSGSFGKVYKGKCRNKI-VAIKRYRPN 495

  Fly   319 T----MSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIY-IVQEYMSKGSLLDFLREGDGRYLH 378
            |    ..|..|.:|.:|:.:..|..::.....|..:...: ||.:|:|.|||...|.| ..|.:.
Zfish   496 TYCSKSDTDMFCREVSILCRLNHPCVIQFVGACLDDPSQFAIVTQYVSGGSLFSLLHE-QKRIID 559

  Fly   379 FEDLIYIATQVASGMEYLE--SKQLIHRDLAARNVLIGENNVAKICDFGLARVI--ADDEYCPKQ 439
            .:..:.||..||.|||||.  ::.:|||||.:.|:|:.|:..|.:.|||.:|.:  .|::...||
Zfish   560 LQSKLIIAIDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLLSVDEDNMTKQ 624

  Fly   440 GSRFPVKWTAPEAIIY-GKFSIKSDVWSYGILLMELFTYGQVPYPGM------------HSREVI 491
            ...  ::|.|||.... .::::|:|::||.:.|.||.| |::|:..:            |.|..|
Zfish   625 PGN--LRWMAPEVFTQCTRYTVKADMFSYALCLWELLT-GEIPFAHLKPAAAAADMAYHHVRPPI 686

  Fly   492 ENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF 530
                 |:.:|||        |..||::.|:..||:||.|
Zfish   687 -----GYSIPKP--------ISALLMRGWNVCPEERPEF 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779
		SH2_Src_family	158..259	CDD:199827	15/69 (22%)
		STYKc	285..537	CDD:214568	86/268 (32%)
		PTKc_Src_like	289..538	CDD:270630	86/264 (33%)
tnni3k	NP_001191752.1	ANK	<56..121	CDD:238125
		Ank_4	67..121	CDD:290365
		ANK repeat	67..98	CDD:293786
		ANK	99..220	CDD:238125
		ANK repeat	100..131	CDD:293786
		Ank_2	105..195	CDD:289560
		ANK repeat	136..164	CDD:293786
		ANK	161..290	CDD:238125
		ANK repeat	166..197	CDD:293786
		Ank_2	171..261	CDD:289560
		ANK repeat	199..232	CDD:293786
		ANK	229..360	CDD:238125
		ANK repeat	269..302	CDD:293786
		Ank_2	274..369	CDD:289560
		ANK repeat	304..337	CDD:293786
		ANK	334..>401	CDD:238125	2/12 (17%)
		ANK repeat	339..369	CDD:293786
		Ank_2	344..>411	CDD:289560	7/23 (30%)
		TyrKc	463..719	CDD:197581	86/268 (32%)
		PKc_TNNI3K	469..722	CDD:270966	86/262 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000