DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and itk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_571179.1	Gene:	itk / 798906	ZFINID:	ZDB-GENE-990415-261	Length:	616	Species:	Danio rerio

Alignment Length:	487	Identity:	187/487 - (38%)
Similarity:	276/487 - (56%)	Gaps:	48/487 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVID 126
            ||||:.|.                :.|.       :|:||||.::..::.:||...|.:...::|
Zfish   156 TPDPSRRS----------------SEPE-------ERIVVALRNFIPKEHTDLPLQKDEEYFIVD 197

  Fly   127 DTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSE--DWFFENVLRKEADKLLLAEENPRGTFLVR 189
            .:|.:||.|.: .....|.:|..:|.|:.|.|.|  :|:.:::.|.||:.||: :||..|.|:||
Zfish   198 CSEPNWWTVKD-KDGNVGSVPCIYVTEKLSNNIEKFEWYNKDINRTEAEDLLM-QENKDGGFMVR 260

  Fly   190 PSEHNPNGYSLSVKDWEDG----RGYHVKHYRIKPLDNGG---YYIATNQTFPSLQALVMAYSKE 247
            .|:| ...|::|:.....|    :...||||:||....|.   ||:|....||::..|: .|.:.
Zfish   261 NSKH-AGVYTVSIFTRVSGSNGEKCPQVKHYQIKVQSEGEKVLYYLAEKYLFPTIPELI-RYHQH 323

  Fly   248 NALGLC----HILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSI 308
            |..||.    |.:||..|. ..::.:|.   .||:||...|::|..:||.|.||.|:.|.|::.
Zfish   324 NPAGLITRLRHCVSRNVPN-SARIKELS---SDKWEIHPDEVKLSVELGSGQFGLVWKGSWQDR- 383

  Fly   309 DVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGD 373
            :|||||:|||.||...|.:||.:|.|..|||||.||.|.:|..|||:|.|:|..|.|.:|||...
Zfish   384 EVAVKTVREGFMSEEEFKEEAQVMMKLSHNRLVQLYGVVTQRSPIYLVFEFMENGCLTEFLRAKK 448

  Fly   374 GRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPK 438
            |: |..:.|:.:...|:.||.||||...|||||||||.|:.||:|.||.|||:.|.:.||:|...
Zfish   449 GK-LSQKALLEMCLDVSEGMAYLESSNFIHRDLAARNCLVSENSVVKIADFGMTRFVLDDQYTSS 512

  Fly   439 QGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKP 503
            .||:|||:|::||.|.:||:|.||||||:|:.:.|:::.|:.||....:.||:|.:..|.|:.||
Zfish   513 HGSKFPVRWSSPEVIKFGKYSSKSDVWSFGVFMWEVYSEGRTPYDNRSNSEVVETLNAGHRLLKP 577

  Fly   504 TNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNH 535
              ...|.::|:|:...|...||.||:|..|.|
Zfish   578 --RLCPQSVYELMQWSWKEKPEDRPSFALLLH 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	14/50 (28%)
		SH2_Src_family	158..259	CDD:199827	38/113 (34%)
		STYKc	285..537	CDD:214568	117/251 (47%)
		PTKc_Src_like	289..538	CDD:270630	116/247 (47%)
itk	NP_571179.1	PH	5..110	CDD:278594
		PH_Btk	7..147	CDD:269944
		SH3_Tec_like	170..223	CDD:212702	15/53 (28%)
		SH2_Tec_family	227..338	CDD:198188	37/113 (33%)
		PKc_like	356..610	CDD:304357	119/256 (46%)
		Pkinase_Tyr	361..609	CDD:285015	117/251 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810