DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and MAP3K12

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001180440.1	Gene:	MAP3K12 / 7786	HGNCID:	6851	Length:	892	Species:	Homo sapiens

Alignment Length:	294	Identity:	96/294 - (32%)
Similarity:	150/294 - (51%)	Gaps:	40/294 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 DKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAI--MKKFRHN 338
            |.:|:|..||..|:.:|.|..|.||.|::... :||||.:|:        |:|..|  ::|.:|.
Human   149 DLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE-EVAVKKVRD--------LKETDIKHLRKLKHP 204

  Fly   339 RLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIH 403
            .::....||:|.....|:.|:.::|.|.:.||.  ||.:....|:..:..:|.||.||...::||
Human   205 NIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLHKIIH 267

  Fly   404 RDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYG 468
            |||.:.|:||..::|.||.|||.::.::|..  .|......|.|.|||.|.....|.|.|:||:|
Human   268 RDLKSPNMLITYDDVVKISDFGTSKELSDKS--TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 330

  Fly   469 ILLMELFTYGQVPYPGMHSREVIENI-ERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF-E 531
            ::|.||.| |::||..:.|..:|..: .....:|.|::  .||....||.|||::.|..||:| :
Human   331 VVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSS--CPDGFKILLRQCWNSKPRNRPSFRQ 392

  Fly   532 FLNH---------------YFESFSVTSEVPYRE 550
            .|.|               ||:     |:..:||
Human   393 ILLHLDIASADVLSTPQETYFK-----SQAEWRE 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779
		SH2_Src_family	158..259	CDD:199827
		STYKc	285..537	CDD:214568	87/270 (32%)
		PTKc_Src_like	289..538	CDD:270630	86/267 (32%)
MAP3K12	NP_001180440.1	STKc_MAP3K12_13	164..400	CDD:270961	85/251 (34%)
MAP3K12	NP_001180440.1	TyrKc	165..397	CDD:197581	84/247 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910