DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and ptk6b

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001070140.1	Gene:	ptk6b / 767734	ZFINID:	ZDB-GENE-060929-1150	Length:	511	Species:	Danio rerio

Alignment Length:	503	Identity:	192/503 - (38%)
Similarity:	281/503 - (55%)	Gaps:	52/503 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GPLKIGGKGGVDI----------------------IRPRTTPTGVPGVVLKRVVVALYDYKSRDE 111
            ||.:..|:..|.:                      |:|...|:......   :.:||:|:|:|::
Zfish    21 GPPQAEGENSVKVDGDFTNKGFDKNETERRYSKPKIKPPLPPSANNNAA---IYMALWDFKARND 82

  Fly   112 SDLSFMKGDRMEVIDDTESDWWRV------VNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRK 170
            .:|||..||:.| |.|...|||..      ..:||   |.:|.|::|.: ||.|:.|||..:.|.
Zfish    83 QELSFKAGDKFE-ITDRSGDWWTANKKDIFGRVTT---GFVPYNYLARD-SVESQPWFFGKMNRV 142

  Fly   171 EADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGG-YYIATNQTF 234
            .|...|:::||..|:||||.||.:..||.|||:..|     :.||::|  ...|. :|:.....|
Zfish   143 GAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKE-----NAKHFKI--FQTGDQFYVDALFKF 200

  Fly   235 PSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEV 299
            .|:..::..| :.:.|.:..:||.||.:.:|:  ::.|...|::|:|:.|.||..:||.|:|.:|
Zfish   201 SSIVEVIEHY-QSHPLSIGDLLSEPCIRIKPE--NVPPPSTDEWELPKEEFQLENQLGSGHFADV 262

  Fly   300 FYGKWRNSIDVAVKTLREG-TMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKG 363
            :.|||:|...||:|.|:.. .:....|..|..|||:.||..|::|:|||:...|.||:.|.:.||
Zfish   263 YSGKWKNHSKVAIKILKNNDALVLREFQLEVQIMKRLRHKHLISLFAVCTSSSPFYIITELIEKG 327

  Fly   364 SLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLAR 428
            .||.|||..:||.|..|.||.:|.|||.||.|||:...|||||||||||:|:..|.||.||||||
Zfish   328 DLLHFLRNPEGRSLQMESLIDMAAQVADGMAYLEANNSIHRDLAARNVLVGDGYVCKIADFGLAR 392

  Fly   429 VIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIEN 493
            :|.:..|. ....:.|.||||||||.:|.:|.||||||:||||.|:.|:|.:||||:::.||.:.
Zfish   393 IIKEPVYL-SDDKKIPYKWTAPEAIGHGTYSSKSDVWSFGILLYEIVTHGGIPYPGVNTGEVYDL 456

  Fly   494 I-ERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESF 540
            | :..:|||.|..  .|..||.::..||......||.|:.|....:::
Zfish   457 ITKENYRMPSPPK--CPQAIYNIMRACWRIESVDRPNFKVLKDELDNY 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	20/56 (36%)
		SH2_Src_family	158..259	CDD:199827	33/101 (33%)
		STYKc	285..537	CDD:214568	120/253 (47%)
		PTKc_Src_like	289..538	CDD:270630	118/250 (47%)
ptk6b	NP_001070140.1	SH3_Brk	70..126	CDD:212781	21/59 (36%)
		SH2	132..216	CDD:214585	29/91 (32%)
		PTKc_Srm_Brk	241..502	CDD:133248	123/263 (47%)
		STYKc	250..499	CDD:214568	119/251 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820