Protein Alignment Src64B and TEC

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_047272062.1
• Gene: TEC / 7006
• HGNCID: 11719
• Length: 722
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 180/452 - (39%)
• Similarity: 261/452 - (57%)
• Gaps: 32/452 - (7%)

  Fly    97 KRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSE- 160
            :.:|||:||:::.:..||...:|....:::..:..|||..: ....||.||.|:|..::|.|.:
Human   272 EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNNLDQ 335

  Fly   161 -DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRG------YHVKHYRI 218
             :|:..|:.|.:|::||.:|:. .|.|:||.|. .|..|::|:.....|.|      ||:|....
Human   336 YEWYCRNMNRSKAEQLLRSEDK-EGGFMVRDSS-QPGLYTVSLYTKFGGEGSSGFRHYHIKETTT 398

  Fly   219 KPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCP---KPQPQMWDLGPELRDKYEI 280
            .|..   ||:|....|.|:..:: .|.|.||.||...|..|..   |..|.......|   |:||
Human   399 SPKK---YYLAEKHAFGSIPEII-EYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYE---KWEI 456

  Fly   281 PRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYA 345
            ..||:..:|:||.|.||.|..||||....||:|.:|||.|....|::||.:|.|..|.:||.||.
Human   457 NPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYG 521

  Fly   346 VCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHF--EDLIYIATQVASGMEYLESKQLIHRDLAA 408
            ||:|::|||||.|:|.:|.||:|||:..|   ||  :.|:.:...|..||||||....|||||||
Human   522 VCTQQKPIYIVTEFMERGCLLNFLRQRQG---HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAA 583

  Fly   409 RNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLME 473
            ||.|:.|..|.|:.|||:||.:.||:|....|::|||||..||...|.:||.||||||:|:|:.|
Human   584 RNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWE 648

  Fly   474 LFTYGQVPYPGMHSREVIENIERGFRM--PKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
            :||.|::|:....:.||:..:.||.|:  ||..::|    :|:::|:||...||.||:||.|
Human   649 VFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNY----VYEVMLRCWQEKPEGRPSFEDL 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	34/108 (31%)
		PTKc_Src_like	289..538	CDD:270630	119/249 (48%)
		SH3_Src_like	99..150	CDD:212779	15/50 (30%)
TEC	XP_047272062.1	PH_Btk	98..239	CDD:269944
		SH3_Tec	273..328	CDD:212838	17/55 (31%)
		SH2_Tec_Itk	331..437	CDD:198259	35/111 (32%)
		PTKc_Tec_Rlk	456..715	CDD:270685	122/258 (47%)