DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and TEC

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_003206.2	Gene:	TEC / 7006	HGNCID:	11719	Length:	631	Species:	Homo sapiens

Alignment Length:	452	Identity:	180/452 - (39%)
Similarity:	261/452 - (57%)	Gaps:	32/452 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 KRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSE- 160
            :.:|||:||:::.:..||...:|....:::..:..|||..: ....||.||.|:|..::|.|.:
Human   181 EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNNLDQ 244

  Fly   161 -DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRG------YHVKHYRI 218
             :|:..|:.|.:|::||.:|:. .|.|:||.|. .|..|::|:.....|.|      ||:|....
Human   245 YEWYCRNMNRSKAEQLLRSEDK-EGGFMVRDSS-QPGLYTVSLYTKFGGEGSSGFRHYHIKETTT 307

  Fly   219 KPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCP---KPQPQMWDLGPELRDKYEI 280
            .|..   ||:|....|.|:..:: .|.|.||.||...|..|..   |..|.......|   |:||
Human   308 SPKK---YYLAEKHAFGSIPEII-EYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYE---KWEI 365

  Fly   281 PRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYA 345
            ..||:..:|:||.|.||.|..||||....||:|.:|||.|....|::||.:|.|..|.:||.||.
Human   366 NPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYG 430

  Fly   346 VCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHF--EDLIYIATQVASGMEYLESKQLIHRDLAA 408
            ||:|::|||||.|:|.:|.||:|||:..|   ||  :.|:.:...|..||||||....|||||||
Human   431 VCTQQKPIYIVTEFMERGCLLNFLRQRQG---HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAA 492

  Fly   409 RNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLME 473
            ||.|:.|..|.|:.|||:||.:.||:|....|::|||||..||...|.:||.||||||:|:|:.|
Human   493 RNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWE 557

  Fly   474 LFTYGQVPYPGMHSREVIENIERGFRM--PKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
            :||.|::|:....:.||:..:.||.|:  ||..::|    :|:::|:||...||.||:||.|
Human   558 VFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNY----VYEVMLRCWQEKPEGRPSFEDL 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	15/50 (30%)
		SH2_Src_family	158..259	CDD:199827	34/108 (31%)
		STYKc	285..537	CDD:214568	119/253 (47%)
		PTKc_Src_like	289..538	CDD:270630	119/249 (48%)
TEC	NP_003206.2	PH_Btk	7..148	CDD:269944
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..178
		SH3_Tec	182..237	CDD:212838	17/55 (31%)
		SH2_Tec_Itk	240..346	CDD:198259	35/111 (32%)
		PTKc_Tec_Rlk	365..624	CDD:270685	122/258 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810