DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and BTK

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001274273.1	Gene:	BTK / 695	HGNCID:	1133	Length:	693	Species:	Homo sapiens

Alignment Length:	505	Identity:	184/505 - (36%)
Similarity:	277/505 - (54%)	Gaps:	50/505 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 NNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLK-----------------RV 99
            |..|||    .|..:||...|            ...||.....:||                 :.
Human   204 NRNGSL----KPGSSHRKTKK------------PLPPTPEEDQILKKPLPPEPAAAPVSTSELKK 252

  Fly   100 VVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAE-ERSVNSEDWF 163
            |||||||...:.:||...|||...:::::...|||..: ...|||.||.|:|.| |.|:...:|:
Human   253 VVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEMYEWY 316

  Fly   164 FENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSV--KDWEDGRGYHVKHYRIKPLDNGGY 226
            .:::.|.:|:: ||.:|...|.|:||.|. ....|::||  |...|.:|. ::||.:.......|
Human   317 SKHMTRSQAEQ-LLKQEGKEGGFIVRDSS-KAGKYTVSVFAKSTGDPQGV-IRHYVVCSTPQSQY 378

  Fly   227 YIATNQTFPSLQALVMAYSKENALGLCHILSRPCP---KPQPQMWDLGPELRDKYEIPRSEIQLL 288
            |:|....|.::..|: .|.:.|:.||...|..|..   |..|....||   ...:||...::..|
Human   379 YLAEKHLFSTIPELI-NYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG---YGSWEIDPKDLTFL 439

  Fly   289 RKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPI 353
            ::||.|.||.|.|||||...|||:|.::||:||...|::||.:|....|.:||.||.||:::.||
Human   440 KELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPI 504

  Fly   354 YIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNV 418
            :|:.|||:.|.||::|||...|: ..:.|:.:...|...||||||||.:||||||||.|:.:..|
Human   505 FIITEYMANGCLLNYLREMRHRF-QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGV 568

  Fly   419 AKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYP 483
            .|:.||||:|.:.||||....||:|||:|:.||.::|.|||.|||:|::|:|:.|:::.|::||.
Human   569 VKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYE 633

  Fly   484 GMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
            ...:.|..|:|.:|.|:.:|  |...:.:|.::..||....::||||:.|
Human   634 RFTNSETAEHIAQGLRLYRP--HLASEKVYTIMYSCWHEKADERPTFKIL 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	20/50 (40%)
		SH2_Src_family	158..259	CDD:199827	29/102 (28%)
		STYKc	285..537	CDD:214568	111/249 (45%)
		PTKc_Src_like	289..538	CDD:270630	110/245 (45%)
BTK	NP_001274273.1	PH	38..167	CDD:278594
		PH_Btk	40..200	CDD:269944
		SH3_BTK	251..305	CDD:212839	22/54 (41%)
		SH2_Tec_Btk	308..413	CDD:198260	31/108 (29%)
		PTKc_Btk_Bmx	431..686	CDD:173657	112/254 (44%)
		Pkinase_Tyr	436..685	CDD:285015	111/249 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810