DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and SRC

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_016883513.1	Gene:	SRC / 6714	HGNCID:	11283	Length:	542	Species:	Homo sapiens

Alignment Length:	519	Identity:	259/519 - (49%)
Similarity:	346/519 - (66%)	Gaps:	33/519 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GGSLDSRYTPD-----PNHRGPLK-----------IGGKGGVD-IIRPRTTPTGVPGVVLKRVVV 101
            ||:..:..||.     ..||||..           .||....| :..|:.......||.   ..|
Human    29 GGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVT---TFV 90

  Fly   102 ALYDYKSRDESDLSFMKGDRMEVIDDT------ESDWWRVVNLTTRQEGLIPLNFVAEERSVNSE 160
            |||||:||.|:||||.||:|::::::|      |.|||...:|:|.|.|.||.|:||...|:.:|
Human    91 ALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 155

  Fly   161 DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGG 225
            :|:|..:.|:|:::|||..||||||||||.||.....|.|||.|:::.:|.:||||:|:.||:||
Human   156 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGG 220

  Fly   226 YYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRK 290
            :||.:...|.|||.||..||| :|.||||.|:..||..:||...|.   :|.:||||..::|..|
Human   221 FYITSRTQFNSLQQLVAYYSK-HADGLCHRLTTVCPTSKPQTQGLA---KDAWEIPRESLRLEVK 281

  Fly   291 LGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYI 355
            ||:|.||||:.|.|..:..||:|||:.||||..||||||.:|||.||.:||.||||.| ||||||
Human   282 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYI 345

  Fly   356 VQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAK 420
            |.||||||||||||:...|:||....|:.:|.|:||||.|:|....:||||.|.|:|:|||.|.|
Human   346 VTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCK 410

  Fly   421 ICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGM 485
            :.||||||:|.|:||..:||::||:|||||||.:||:|:|||||||:||||.||.|.|:||||||
Human   411 VADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM 475

  Fly   486 HSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
            .:|||::.:|||:|||.|..  .|::::.|:.|||...||:|||||:|..:.|.:..::|..|:
Human   476 VNREVLDQVERGYRMPCPPE--CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	27/56 (48%)
		SH2_Src_family	158..259	CDD:199827	52/100 (52%)
		STYKc	285..537	CDD:214568	149/251 (59%)
		PTKc_Src_like	289..538	CDD:270630	148/248 (60%)
SRC	XP_016883513.1	SH3_Src	88..149	CDD:212941	30/60 (50%)
		SH2_Src_Src	153..253	CDD:198228	52/100 (52%)
		PTKc_Src	266..542	CDD:270656	157/275 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6763
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21120
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.820