Protein Alignment Src64B and BMX

DIOPT Version :9

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001712.1
• Gene: BMX / 660
• HGNCID: 1079
• Length: 675
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 202/606 - (33%)
• Similarity: 288/606 - (47%)
• Gaps: 109/606 - (17%)

  Fly     9 RQDQELALAYPTGGYKKSDYTFGQTHINSSGGGNMGGVLGQKHNNGGSLDSRYTPDPNHRGP--- 70
            |.:..|.:.|.:|.:....:...|....::.|..:.......|.        ...:..||.|
Human   111 RGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHT--------AVNEEKHRVPTFP 167

  Fly    71 ---LKIGGKGGVDIIRPRTTPTGVPGVVLK------RVVVALYDYKSR-------DESDLSFMKG 119
               |||          ||..|      |||      ...:|.||.:|:       ..|..|..:.
Human   168 DRVLKI----------PRAVP------VLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQY 216

  Fly   120 D-------------RMEVIDDTE-SDWWRV---------------------VNLTTRQEGLIPLN 149
            |             .|:.|...: .|||:|                     ||.||.:   |...
Human   217 DSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSK---ISWE 278

  Fly   150 F-----VAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSV--KDWED 207
            |     ..||.:::..|||..|:.|.:::: ||.::...|.|:||.|. ....|::|:  |...|
Human   279 FPESSSSEEEENLDDYDWFAGNISRSQSEQ-LLRQKGKEGAFMVRNSS-QVGMYTVSLFSKAVND 341

  Fly   208 GRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPC---PKPQPQMWD 269
            .:| .||||.:........|:|.|..|.|:..|: .|.:.|:.|:...|..|.   ....|....
Human   342 KKG-TVKHYHVHTNAENKLYLAENYCFDSIPKLI-HYHQHNSAGMITRLRHPVSTKANKVPDSVS 404

  Fly   270 LGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKK 334
            ||..:   :|:.|.||.||::||.|.||.|..|||:...|||||.::||:||...|.|||..|.|
Human   405 LGNGI---WELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMK 466

  Fly   335 FRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESK 399
            ..|.:||..|.|||:|.|||||.||:|.|.||::|| ..|:.|....|:.:...|..||.:|||.
Human   467 LSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLR-SHGKGLEPSQLLEMCYDVCEGMAFLESH 530

  Fly   400 QLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDV 464
            |.|||||||||.|:..:...|:.|||:.|.:.||:|....|::|||||:|||...|.|:|.||||
Human   531 QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDV 595

  Fly   465 WSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPT 529
            |::|||:.|:|:.|:.||....:.:|:..:.:|.|:.:|  |...|.|||::..||..:||||||
Human   596 WAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRP--HLASDTIYQIMYSCWHELPEKRPT 658

  Fly   530 FEFLNHYFESFSVTSEVPYRE 550
            |:.|        ::|..|.||
Human   659 FQQL--------LSSIEPLRE 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	18/92 (20%)
		SH2_Src_family	158..259	CDD:199827	31/102 (30%)
		STYKc	285..537	CDD:214568	120/251 (48%)
		PTKc_Src_like	289..538	CDD:270630	117/248 (47%)
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944	6/35 (17%)
		SH2_Tec_Bmx	289..394	CDD:198262	32/108 (30%)
		PTKc_Btk_Bmx	412..667	CDD:173657	123/265 (46%)
		CAV1-binding	596..603		4/6 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910