DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and SLA

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_006739.2	Gene:	SLA / 6503	HGNCID:	10902	Length:	316	Species:	Homo sapiens

Alignment Length:	213	Identity:	78/213 - (36%)
Similarity:	102/213 - (47%)	Gaps:	33/213 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GQKHNNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDES 112
            |:|...|.|:.|  ||.|..               ||...|.|:....|    ..|.||.|.|.|
Human    36 GKKKEMGNSMKS--TPAPAE---------------RPLPNPEGLDSDFL----AVLSDYPSPDIS 79

  Fly   113 DLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLL 177
            ...|.:|:::.||.| |..||:.::|:|.:|..||...||..    ...|.||.:.|.:|::||.
Human    80 PPIFRRGEKLRVISD-EGGWWKAISLSTGRESYIPGICVARV----YHGWLFEGLGRDKAEELLQ 139

  Fly   178 AEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVM 242
            ..:...|:|::|.||.....|||||      |...||||||..|.|..|||:...||..|:.||.
Human   140 LPDTKVGSFMIRESETKKGFYSLSV------RHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVN 198

  Fly   243 AYSKENALGLCHILSRPC 260
            .|| |.|.|||.:|:.||
Human   199 HYS-EVADGLCCVLTTPC 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	19/50 (38%)
		SH2_Src_family	158..259	CDD:199827	42/100 (42%)
		STYKc	285..537	CDD:214568
		PTKc_Src_like	289..538	CDD:270630
SLA	NP_006739.2	SH3_SLAP	66..120	CDD:212943	22/58 (38%)
SLA	NP_006739.2	SH2_SLAP	113..210	CDD:198207	44/107 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910