DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and fynb

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001025140.1	Gene:	fynb / 574422	ZFINID:	ZDB-GENE-050706-89	Length:	544	Species:	Danio rerio

Alignment Length:	561	Identity:	263/561 - (46%)
Similarity:	364/561 - (64%)	Gaps:	34/561 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNKCCSKRQ------DQELALAYPTGGYKKSDYTFGQTHINSSGGGNMGGVLGQKHN-NGGSLD 58
            ||...|..::      |::.:|:....||:.......|.:...||.|.....:...:| :|.::.
Zfish     1 MGCVQCKDKEAAKLTDDRDTSLSQSGVGYRYGVDPTPQHYPAFSGTGTAVAAIPNYNNFHGAAVP 65

  Fly    59 SRYT-----PDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMK 118
            ...|     ....|:|.|:..|..||.:.                  ||||||::|.|.||||.|
Zfish    66 QGMTVFGGISTSTHQGTLRTRGGTGVTLF------------------VALYDYEARTEDDLSFRK 112

  Fly   119 GDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPR 183
            |::.::|:.||.|||...:|||...|.||.|:||...|:.:|||:|..:.||:|::.||:..|||
Zfish   113 GEKFQIINSTEGDWWDARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPR 177

  Fly   184 GTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKEN 248
            ||||:|.||.....:|||::||:|.:|.|||||:|:.||:|||||.|...|.:||.||..|: |.
Zfish   178 GTFLIRESETTKGAFSLSIRDWDDVKGDHVKHYKIRKLDSGGYYITTRAQFETLQQLVQHYT-ER 241

  Fly   249 ALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVK 313
            |.|||..|..||.|..|::.||..:.:|.:||||..:||:::||.|.||||:.|.|..:..||:|
Zfish   242 AAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIK 306

  Fly   314 TLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLH 378
            ||:.||||..:||:||.||||.||::||.||||.| |||||||.|||.||||||||::|:||.|.
Zfish   307 TLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEYMGKGSLLDFLKDGEGRALK 370

  Fly   379 FEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRF 443
            ..:|:.:|.|||.||.|:|....|||||.:.|:|:|::.|.||.||||||:|.|:||..:||::|
Zfish   371 LPNLVDMAAQVAGGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKF 435

  Fly   444 PVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF 508
            |:|||||||.:||||:|||||||:||||.||.|.|:||||||::|||:|.:|||:||..|.:  .
Zfish   436 PIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMQCPQD--C 498

  Fly   509 PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
            |.::::|::|||....|:|||||:|..:.|.:...:|..|:
Zfish   499 PSSLHELMVQCWKKDAEERPTFEYLQAFLEDYFTATEPQYQ 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	26/50 (52%)
		SH2_Src_family	158..259	CDD:199827	52/100 (52%)
		STYKc	285..537	CDD:214568	147/251 (59%)
		PTKc_Src_like	289..538	CDD:270630	145/248 (58%)
fynb	NP_001025140.1	SH3_Fyn_Yrk	92..147	CDD:212939	28/72 (39%)
		SH2_Src_Fyn_isoform_a_like	152..252	CDD:198281	52/100 (52%)
		PKc_like	268..541	CDD:304357	155/275 (56%)
		Pkinase_Tyr	278..527	CDD:285015	147/251 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6487
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.780