DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and tec

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001108215.1	Gene:	tec / 571588	ZFINID:	ZDB-GENE-030131-7499	Length:	622	Species:	Danio rerio

Alignment Length:	442	Identity:	168/442 - (38%)
Similarity:	251/442 - (56%)	Gaps:	39/442 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 RTTPTGVPGVVL-------KRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQ 142
            |..|...||...       :.||:||||::..:..||:...|:...:::..|.:|::..|...:|
Zfish   171 RRPPPPPPGETKQEEEEPEEEVVIALYDFEGLEPHDLTLKTGEEYVILEKCEVNWYKARNKEGKQ 235

  Fly   143 EGLIPLNFVAEERSVNSED--WFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSV--K 203
             |.||.|:|.|:.|...|.  ||.:||.|.:|:: ||.:|...|.|:||.|. |...|::|:  |
Zfish   236 -GYIPSNYVTEKASDKLEQFIWFSKNVNRNKAEE-LLRKEGKEGGFMVRLSS-NTGTYTVSLYTK 297

  Fly   204 DWEDGRGYHVKHYRIKPLDNG--GYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQ 266
            ...||.. .::||:||.:...  .:|:|....|.|:..|: .|.|.||.||...|...
Zfish   298 STSDGAA-AIRHYQIKEIHASPKQFYLAEKYIFTSIPELI-EYHKHNAAGLVSRLRHA------- 353

  Fly   267 MWDLGPELR----------DKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMS 321
               :|.:.|          ||:||..||:..:::||.|.||.|..||||....||:||:|||.||
Zfish   354 ---VGDQKREAPTTAGFSYDKWEINPSELTFMKELGSGQFGVVRLGKWRAQHKVAIKTIREGAMS 415

  Fly   322 TAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIA 386
            ...|::||.||....|..||.||.||:|::|||:|.|:|..|.||:|||:..|. |..:||:.|.
Zfish   416 EDDFIEEAKIMMNLSHRNLVQLYGVCTQQKPIYLVTEFMELGCLLNFLRQRRGT-LAAQDLLGIC 479

  Fly   387 TQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPE 451
            ..::.||::||..:.|||||||||.|:..:.|.|:.|||:.|.:.||:|....|::|||||:.||
Zfish   480 HDISQGMQHLEENRFIHRDLAARNCLVNTSMVVKVSDFGMTRYVLDDQYWSSSGTKFPVKWSPPE 544

  Fly   452 AIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKP 503
            ...:.::|.||||||:|:|:.|:||.|::|:....:.||:..:.:|.|:.:|
Zfish   545 VFNFCRYSSKSDVWSFGVLMWEVFTEGKMPFEHSQNHEVVLMVTQGHRLYRP 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	16/50 (32%)
		SH2_Src_family	158..259	CDD:199827	37/106 (35%)
		STYKc	285..537	CDD:214568	99/219 (45%)
		PTKc_Src_like	289..538	CDD:270630	99/215 (46%)
tec	NP_001108215.1	PH	6..111	CDD:278594
		PH_Btk	7..148	CDD:269944
		SH3_Tec	192..246	CDD:212838	18/54 (33%)
		SH2_Tec_Itk	249..356	CDD:198259	37/120 (31%)
		PKc_like	374..602	CDD:304357	102/224 (46%)
		Pkinase_Tyr	379..602	CDD:285015	99/219 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910