DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and btk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_021336920.1	Gene:	btk / 568653	ZFINID:	ZDB-GENE-070531-1	Length:	640	Species:	Danio rerio

Alignment Length:	549	Identity:	185/549 - (33%)
Similarity:	283/549 - (51%)	Gaps:	73/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KCCSKRQDQEL---ALAYPTGGYKKSDYTFGQTHINSSGGGNMGGVLGQKHNNGGSLDSR--YTP 63
            |||.:...|.:   .|....||..|.                     |.|:.     |||  ..|
Zfish   132 KCCLQEVKQAMGCRVLETKNGGVFKR---------------------GSKNR-----DSRKPLPP 170

  Fly    64 DPNHRGPLKIGGKGGVDIIRP-RTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDD 127
            .|....|           .|| ...|...|...:...|:|.|:|.....:||...|.:...:::.
Zfish   171 TPEEEKP-----------ARPLPPEPPMPPAFSIGMTVIAEYEYAPMTTNDLELRKDEEYTLLEI 224

  Fly   128 TESDWWRVVNLTTRQEGLIPLNFVAEE-RSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPS 191
            ::.:|::..: ...:||.||.|::.:. ..:...||:.:|:.|.:|:. ||..||..|.||||.|
Zfish   225 SDPNWFKAKD-KYGKEGYIPSNYIVQALNGLEKYDWYCKNINRSQAEN-LLKTENKDGGFLVRDS 287

  Fly   192 EHNPNGYSLSVKDWEDGR-GYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLC-- 253
            ......|::||.....|. ....:||.|....:|.:|:|....|.::..|: .|.:.||.||.
Zfish   288 GKFTGKYTVSVFTKAGGETSGSCRHYNILLTADGQFYLAEKHNFTNIPELI-NYHQHNAAGLVSR 351

  Fly   254 --HILSR-----PCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVA 311
              :|:|.     ||..      .||   ...:||...::..:|:||.|.||.|.||||:...|||
Zfish   352 LKYIVSNRAQNAPCTA------GLG---YGSWEIDPRQLTFIRELGNGQFGVVKYGKWQGRHDVA 407

  Fly   312 VKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRY 376
            :|.::||:||...|::||.:|.|..|..||.||.||:::.|||||.||::.|.||::|:||   .
Zfish   408 IKMVKEGSMSEDDFIEEAKVMMKLCHGNLVQLYGVCTKQRPIYIVTEYLANGCLLNYLQEG---L 469

  Fly   377 LHFED--LIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQ 439
            |:...  |:.:...|:.||:|||:.|.|||||||||.|:..|...|:.||||:|.:.||||....
Zfish   470 LNPTSIALLEMCKDVSEGMKYLEANQFIHRDLAARNCLVDSNGTIKVTDFGLSRYVLDDEYTSSV 534

  Fly   440 GSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPT 504
            ||:|||:|:.||.::|.|||.|||:|::|:|:.|::|.|::||...::.|::|.|..|.|:.:|
Zfish   535 GSKFPVRWSPPEVLLYCKFSSKSDIWAFGVLMWEIYTQGRMPYDRWNNTEIVEKISAGHRLYRP- 598

  Fly   505 NHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
             ....:|::.::..||...|::||||:.|
Zfish   599 -QMANENVFAIMNSCWHERPDERPTFQEL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	12/50 (24%)
		SH2_Src_family	158..259	CDD:199827	34/110 (31%)
		STYKc	285..537	CDD:214568	112/251 (45%)
		PTKc_Src_like	289..538	CDD:270630	112/247 (45%)
btk	XP_021336920.1	PH_Btk	6..145	CDD:269944	4/12 (33%)
		SH3	195..249	CDD:327375	13/54 (24%)
		SH2	252..357	CDD:326550	33/106 (31%)
		PKc_like	376..630	CDD:328722	113/256 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910