DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and frk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_021324228.1	Gene:	frk / 567549	ZFINID:	ZDB-GENE-110411-7	Length:	512	Species:	Danio rerio

Alignment Length:	500	Identity:	235/500 - (47%)
Similarity:	317/500 - (63%)	Gaps:	36/500 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 DPNHRGPLKIGGKGGVDII-----RPRT---TPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGD 120
            ||: ..|....||..:::|     :|:.   .||.|       :.||||||.:|.:.||||..||
Zfish    21 DPD-TSPSPDTGKRHIEVITNEFAKPQNRELPPTPV-------LYVALYDYTARTDDDLSFNAGD 77

  Fly   121 RMEVIDDTESDWW---RVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENP 182
            ::|.|...| |||   .:..::..::|.||.|:||...|:::|.|:|....|.:|:|:|:::||.
Zfish    78 KLEPITKGE-DWWFSKAITGISANKKGYIPANYVAPVESLDAEPWYFPETKRSDAEKMLISQENK 141

  Fly   183 RGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKE 247
            :|.||:|..|..|...||||:|     ...||||:|:.|||||||::|.:.||:|:.||..|||.
Zfish   142 KGAFLIRNCESQPGELSLSVRD-----DVKVKHYKIRKLDNGGYYLSTARNFPTLRELVEHYSKH 201

  Fly   248 NALGLCHILSRPCPKP-QPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVA 311
            .. |||..|:.||.|. .|:...|.....|::||.||.::||::||.|.|||||.|.|.::..||
Zfish   202 ED-GLCVRLAEPCKKSVAPETHGLSYNTVDQWEIERSSVKLLKQLGAGQFGEVFEGLWNDTTPVA 265

  Fly   312 VKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRY 376
            ||||:.|.|....||:||.||||.||::|:.|||||:.||||||:.|.||.||||::|:...|..
Zfish   266 VKTLKPGNMDPKDFLREAQIMKKLRHSKLIQLYAVCTLEEPIYIITELMSNGSLLEYLQNDRGAT 330

  Fly   377 LHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVI----ADDEYCP 437
            |...|.|.:..||||||.|||.:..|||||||||||:|:|||.|:.|||||||.    .|:.|..
Zfish   331 LRMSDQIDMGAQVASGMAYLELQNYIHRDLAARNVLVGDNNVCKVADFGLARVFQMDNEDNVYEA 395

  Fly   438 KQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPK 502
            |:|::|||||||||||...||:|||||||:||||.|:.|:||.|||.|.:.:|::.:.:|:||..
Zfish   396 KEGTKFPVKWTAPEAINENKFTIKSDVWSFGILLYEIVTFGQTPYPTMTNFQVVQQLPKGYRMSS 460

  Fly   503 PTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESF---SVTS 544
            |.|.:  ..:|.::|.||..||..|||||.|....|.|   .:||
Zfish   461 PPNCH--KCLYDIMLDCWKDVPADRPTFETLQWKLEDFFDMDITS 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	22/53 (42%)
		SH2_Src_family	158..259	CDD:199827	45/100 (45%)
		STYKc	285..537	CDD:214568	140/255 (55%)
		PTKc_Src_like	289..538	CDD:270630	138/252 (55%)
frk	XP_021324228.1	SH3_Src_like	56..109	CDD:212779	22/53 (42%)
		SH2_Src_family	117..212	CDD:199827	45/100 (45%)
		PTKc_Frk_like	230..500	CDD:270653	147/271 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820