DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and csk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001071067.1	Gene:	csk / 556454	ZFINID:	ZDB-GENE-061103-493	Length:	450	Species:	Danio rerio

Alignment Length:	479	Identity:	179/479 - (37%)
Similarity:	269/479 - (56%)	Gaps:	50/479 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDT-ESDWWRVVNLTTRQEGLIPLN 149
            |.|.|..       .||.|::....:.||...|||.:.::..| :.:|:|..|...| ||.||.|
Zfish     7 TWPAGTE-------CVARYNFPGTADQDLPMCKGDVLTIVGVTKDPNWYRAKNSAGR-EGTIPAN 63

  Fly   150 FVAEERSVNSED------WFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDG 208
            :|.:...|.|..      ||...:.|::|::||...|.  |.||||.|.:.|..|:|.|..  ||
Zfish    64 YVQKREGVKSASKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSC--DG 124

  Fly   209 RGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPE 273
            :   |:|||| ...||...|...:.|.:|..|:..|:|: |.|||..|.:      |::.:....
Zfish   125 K---VEHYRI-IYHNGKLSIDEEEYFENLMQLMEHYTKD-ADGLCTRLIK------PKIMEGTVA 178

  Fly   274 LRDKYE-----IPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMK 333
            .:|::.     :.|.|::|::.:|:|.||:|..|.:|.. .||||.::... :..||:.||::|.
Zfish   179 AQDEFSRSGWALNRKELKLIQTIGKGEFGDVMVGDYRGK-KVAVKCIKHDA-TAQAFVAEASVMT 241

  Fly   334 KFRHNRLVALYAVCSQEE-PIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLE 397
            :.|||.||.|..|..:|: .:|||.|||:||||:|:||......:..:.||..:..|...|||||
Zfish   242 QLRHNNLVQLLGVIVEEKGSLYIVTEYMAKGSLVDYLRSRGRTVIGGDRLINFSMDVCKAMEYLE 306

  Fly   398 SKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKS 462
            :...:||||||||||:.|:|:||:.||||.:..:..:    ..::.|||||:|||:...|||.||
Zfish   307 ANNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQ----DTAKLPVKWTSPEALREKKFSTKS 367

  Fly   463 DVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCW--DAVPE 525
            |||||||||.|::::|:||||.:..:||:..:|:|::|..|..  .|..:|.::.|||  |||
Zfish   368 DVWSYGILLWEIYSFGRVPYPRIPLKEVVPRVEKGYKMDSPDG--CPPVVYDIMKQCWTLDAV-- 428

  Fly   526 KRPTFEFLNHYFESFSVTSEVPYR 549
            .||:|..|....:.. :|:|: ||
Zfish   429 VRPSFRDLREKLQDI-ITNEL-YR 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	17/51 (33%)
		SH2_Src_family	158..259	CDD:199827	38/106 (36%)
		STYKc	285..537	CDD:214568	110/254 (43%)
		PTKc_Src_like	289..538	CDD:270630	109/251 (43%)
csk	NP_001071067.1	SH3_CSK	11..67	CDD:212703	20/63 (32%)
		SH2_csk_like	78..175	CDD:198190	38/111 (34%)
		PTKc_Csk	188..443	CDD:133213	112/264 (42%)
		STYKc	195..440	CDD:214568	110/254 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810