DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and lyn

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_012820235.2	Gene:	lyn / 549989	XenbaseID:	XB-GENE-1015126	Length:	508	Species:	Xenopus tropicalis

Alignment Length:	499	Identity:	227/499 - (45%)
Similarity:	335/499 - (67%)	Gaps:	30/499 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 YTPDPNHRGPLKIGGKGGVDIIRP-RTTPTGVPGVVLKR-------VVVALYDYKSRDESDLSFM 117
            |.|||..:            :.|| ..||:.:||..:.:       :|:|||.|:...:.||:|.
Frog    29 YVPDPTAK------------LQRPVSRTPSLLPGQKILQEIEEQGNIVIALYPYQGIHQDDLTFK 81

  Fly   118 KGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENP 182
            ||::::||:: ..:||:..:|:|::||.||.|:||...::.:|:|||:::.||:|::.|||..|.
Frog    82 KGEKLKVIEE-HGEWWKAKSLSTKKEGFIPSNYVARVNTLETEEWFFKDITRKDAERQLLAPGNN 145

  Fly   183 RGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKE 247
            .|.||:|.||.:...||||::|::...|..:|||:|:.||||||||:...||.|:..::..|.|:
Frog   146 PGAFLIRESETSKGSYSLSIRDYDPKTGDVIKHYKIRTLDNGGYYISPRITFTSICDMIQHYQKQ 210

  Fly   248 NALGLCHILSRPCPKPQPQM-WDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVA 311
             |.|||..|.:||..|:||. ||     :|.:||||..|:|::|||.|.||||:.|.:.||..||
Frog   211 -ADGLCRKLDKPCYSPKPQKPWD-----KDAWEIPRESIKLVKKLGAGQFGEVWMGFYNNSTKVA 269

  Fly   312 VKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRY 376
            ||||:.||||..||::||.:||..:|::||.||||.|:||||||:.|:|:||||||||:..:|..
Frog   270 VKTLKPGTMSVQAFMEEANLMKSLQHDKLVRLYAVVSKEEPIYIITEFMAKGSLLDFLKSDEGAK 334

  Fly   377 LHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGS 441
            :....||..:.|:|.||.|:|.|..|||||.|.|||:.|:.:.||.||||||||.|:||..::|:
Frog   335 VILPKLIDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGA 399

  Fly   442 RFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNH 506
            :||:||||||||.:|.|:|||||||:|:||.|:.|.|::|||||.:.:|:..::||:|||:..|
Frog   400 KFPIKWTAPEAINFGSFTIKSDVWSFGVLLYEIITTGKIPYPGMSNSDVMTALQRGYRMPRMEN- 463

  Fly   507 YFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYRE 550
             .|..:|.::.:||....|:||||::|....:.|...:|..|::
Frog   464 -CPVELYDIMKECWKEKAEERPTFDYLQSVLDDFYTATEAQYQQ 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	20/50 (40%)
		SH2_Src_family	158..259	CDD:199827	45/100 (45%)
		STYKc	285..537	CDD:214568	134/251 (53%)
		PTKc_Src_like	289..538	CDD:270630	132/248 (53%)
lyn	XP_012820235.2	SH3_Lyn	63..118	CDD:212937	23/55 (42%)
		SH2_Src_Lyn	121..221	CDD:198227	45/100 (45%)
		PTKc_Lyn	235..506	CDD:270657	141/272 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010