DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and Tnni3k

DIOPT Version :9

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_796040.3 Gene:Tnni3k / 435766 MGIID:2443276 Length:834 Species:Mus musculus


Alignment Length:491 Identity:140/491 - (28%)
Similarity:210/491 - (42%) Gaps:138/491 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 VVNLTTRQEGLIPL-------NF-VAEE-------RSVNSEDWFFENVLR------KEAD--KLL 176
            |:|:    .|..||       || ||:|       .|:..|:.|.|....      |..|  |.|
Mouse   264 VINI----YGDTPLHLACYNGNFEVAKEIVHVTGTESLTKENIFSETAFHSACTYGKNIDLVKFL 324

  Fly   177 LAEE----NPRG----TFLVRPSEHN---------PNGYSLSV-----------KD------WED 207
            |.:.    |.||    |.|.....|.         .||..:::           ||      |..
Mouse   325 LDQNAVNINHRGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAY 389

  Fly   208 GRGYH-----VKHYRIKPLD-----------NGGYYIATNQTFPSLQALVMAYSKENALGLCHIL 256
            .:|:.     :|||: :|.|           ..|.|::.    ||....:.:.:||.|..|.   
Mouse   390 EKGHDAIVTLLKHYK-RPQDELPCNEYSQPGGDGSYVSV----PSPLGKIKSMTKEKADVLL--- 446

  Fly   257 SRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMS 321
                         |..||..::.:..|||:....:|.|:||:|:.|:.||.| ||:|..|..|..
Mouse   447 -------------LRAELPSRFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKI-VAIKRYRANTYC 497

  Fly   322 TAA----FLQEAAIMKKFRHNRLVALYAVCSQEEPIY-IVQEYMSKGSLLDFLREGDGRYLHFED 381
            :.:    |.:|.:|:.:..|..:|.....|..:...: ||.:|:|.|||...|.| ..|.|..:.
Mouse   498 SKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHE-QKRILDLQS 561

  Fly   382 LIYIATQVASGMEYLES--KQLIHRDLAARNVLIGENNVAKICDFGLARVI--ADDEYCPKQGSR 442
            .:.||..||.|||||.|  :.:|||||.:.|:|:.|:..|.:.|||.:|.:  .|::...||...
Mouse   562 KLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGN 626

  Fly   443 FPVKWTAPEAIIY-GKFSIKSDVWSYGILLMELFTYGQVPYPGM------------HSREVIENI 494
              ::|.|||.... .:::||:||:||.:.|.||.| |::|:..:            |.|..|   
Mouse   627 --LRWMAPEVFTQCTRYTIKADVFSYALCLWELLT-GEIPFAHLKPAAAAADMAYHHIRPPI--- 685

  Fly   495 ERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF 530
              |:.:|||        |..||::.|:|.||.||.|
Mouse   686 --GYSIPKP--------ISSLLMRGWNACPEGRPEF 711

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH3_Src_like 99..150 CDD:212779 5/21 (24%)
SH2_Src_family 158..259 CDD:199827 33/158 (21%)
STYKc 285..537 CDD:214568 91/268 (34%)
PTKc_Src_like 289..538 CDD:270630 90/264 (34%)
Tnni3kNP_796040.3 ANK repeat 66..98 CDD:293786
ANK 1 66..96
Ank_2 71..164 CDD:289560
ANK 99..220 CDD:238125
ANK repeat 100..131 CDD:293786
ANK 2 100..129
ANK 3 133..162
ANK repeat 134..164 CDD:293786
Ank_2 138..231 CDD:289560
ANK 161..289 CDD:238125 10/28 (36%)
ANK repeat 166..197 CDD:293786
ANK 4 166..195
ANK repeat 199..231 CDD:293786
ANK 5 199..229
ANK 228..359 CDD:238125 25/98 (26%)
ANK 6 233..262
Ank_4 237..286 CDD:290365 8/25 (32%)
ANK repeat 268..301 CDD:293786 9/32 (28%)
ANK 7 268..297 8/28 (29%)
Ank_2 273..368 CDD:289560 23/94 (24%)
ANK repeat 303..336 CDD:293786 8/32 (25%)
ANK 8 303..334 7/30 (23%)
ANK 333..>400 CDD:238125 12/66 (18%)
ANK repeat 338..368 CDD:293786 5/29 (17%)
ANK 9 338..367 5/28 (18%)
Ank_4 339..400 CDD:290365 9/60 (15%)
ANK 10 380..409 7/29 (24%)
TyrKc 462..718 CDD:197581 91/268 (34%)
PKc_TNNI3K 468..721 CDD:270966 90/262 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..834
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X88
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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