DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and FER

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	150/408 - (36%)
Similarity:	223/408 - (54%)	Gaps:	45/408 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 VAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKH 215
            ::..|.:..|:||...:.|:|..:||    |..|.||||.:..|.....:....|   .|:  ||
  Fly   949 LSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSVCW---NGH--KH 1004

  Fly   216 YRIKPLDNGGYYIATNQTFPSLQALVM-AYSKENALGLCH--ILSRP-CPKPQPQMWDLGPELRD 276
            :.::....|.:.. ....|.|:|.|:| .|..|..:.:..  ||.|| |              |:
  Fly  1005 FIVQTTGEGNFRF-EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVC--------------RE 1054

  Fly   277 KYEIPRSEIQLLRKLGRGNFGEVFYGKWRNS-IDVAVKTLREGTM---STAAFLQEAAIMKKFRH 337
            ::|:...::.||.::||||||:|:..|.::: :||||||.|. |:   ....||||..|:|::.|
  Fly  1055 RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDH 1118

  Fly   338 NRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLI 402
            ..:|.|..:|.|::||.||.|.:..||||.:||: :...|.....:.:....|:||.|||||..|
  Fly  1119 PNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK-NSNGLTTRQQMGMCRDAAAGMRYLESKNCI 1182

  Fly   403 HRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQG-SRFPVKWTAPEAIIYGKFSIKSDVWS 466
            ||||||||.|:...:..||.|||::|  .::||....| .:.|||||||||:.:||::...||||
  Fly  1183 HRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWS 1245

  Fly   467 YGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFE 531
            ||||:.|:|:.|..||.||.:....|.|:.|:|||.|.:  .|:.:|:|:||||.|..|.||
  Fly  1246 YGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKS--TPEEMYRLMLQCWAADAESRP--- 1305

  Fly   532 FLNHYFESFSVTSEVPYR 549
               |:.|.::|...:..|
  Fly  1306 ---HFDEIYNVVDALILR 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779
		SH2_Src_family	158..259	CDD:199827	28/103 (27%)
		STYKc	285..537	CDD:214568	113/256 (44%)
		PTKc_Src_like	289..538	CDD:270630	111/253 (44%)
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/95 (28%)
		TyrKc	1063..1311	CDD:197581	114/259 (44%)
		PTKc_Fes_like	1067..1315	CDD:270637	113/259 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468361
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950