DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and LCK

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_024302814.1	Gene:	LCK / 3932	HGNCID:	6524	Length:	567	Species:	Homo sapiens

Alignment Length:	514	Identity:	232/514 - (45%)
Similarity:	327/514 - (63%)	Gaps:	30/514 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GQKHNNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTG----------VPGVVLKRVVVA 102
            |.|....|||...:...|.:..|       |:..:.|.....|          :|.|....:|:|
Human    69 GLKDKACGSLAVGFHLSPTYFLP-------GLAFLVPHPVTPGFLPIPARFSLMPLVFTDNLVIA 126

  Fly   103 LYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENV 167
            |:.|:...:.||.|.||:::.:::.: .:||:..:|||.|||.||.||||:..|:..|.|||:|:
Human   127 LHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNL 190

  Fly   168 LRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQ 232
            .||:|::.|||..|..|:||:|.||.....:||||:|::..:|..||||:|:.|||||:||:...
Human   191 SRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRI 255

  Fly   233 TFPSLQALVMAYSKENALGLCHILSRPC--PKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGN 295
            |||.|..||..|:..:. |||..|||||  .|||...|:      |::|:||..::|:.:||.|.
Human   256 TFPGLHELVRHYTNASD-GLCTRLSRPCQTQKPQKPWWE------DEWEVPRETLKLVERLGAGQ 313

  Fly   296 FGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYM 360
            ||||:.|.:.....||||:|::|:||..|||.||.:||:.:|.|||.||||.:| |||||:.|||
Human   314 FGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQ-EPIYIITEYM 377

  Fly   361 SKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFG 425
            ..|||:|||:...|..|....|:.:|.|:|.||.::|.:..|||||.|.|:|:.:....||.|||
Human   378 ENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFG 442

  Fly   426 LARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREV 490
            |||:|.|:||..::|::||:||||||||.||.|:|||||||:||||.|:.|:|::|||||.:.||
Human   443 LARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEV 507

  Fly   491 IENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
            |:|:|||:||.:|.|  .|:.:|||:..||...||.||||::|....|.|...:|..|:
Human   508 IQNLERGYRMVRPDN--CPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQ 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	19/50 (38%)
		SH2_Src_family	158..259	CDD:199827	48/100 (48%)
		STYKc	285..537	CDD:214568	133/251 (53%)
		PTKc_Src_like	289..538	CDD:270630	132/248 (53%)
LCK	XP_024302814.1	SH3_Lck	123..176	CDD:212938	22/53 (42%)
		SH2_Src_Lck	181..281	CDD:198225	48/100 (48%)
		PTKc_Lck_Blk	295..558	CDD:270652	138/265 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820