DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Ack

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster

Alignment Length:	340	Identity:	115/340 - (33%)
Similarity:	172/340 - (50%)	Gaps:	47/340 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 PSLQALVMAYSKENALGLCH-----ILSR-------PCPKPQPQMWDLGPELRDKYE-------- 279
            |:::.|:.|..|:.|    |     |||:       |..|.|      ....|:..:
  Fly    62 PAIRRLMEAVRKKKA----HQWRKNILSKLIGGGKQPSSKKQ------SSAARESSQGNGTQLTC 116

  Fly   280 -IPRSEIQLLRKLGRGNFGEVFYGKWRNS-----IDVAVKTLREGTMSTAA----FLQEAAIMKK 334
             |...:|.:..|||.|:||.|..|:|..|     |.||||.|:...::...    |.:|...|..
  Fly   117 LIHEKDITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHA 181

  Fly   335 FRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESK 399
            ..|..||.||.|. ..:|:.::.|...:|||||.||: ..|:.....:...:.|:.:||.|||.|
  Fly   182 LDHANLVRLYGVV-LSQPMMMITELAERGSLLDTLRK-QCRHTSLTIIWNWSVQIVTGMAYLEQK 244

  Fly   400 QLIHRDLAARNVLIGENNVAKICDFGLARVI--ADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKS 462
            :.:|||||.||||:...|..||.||||.|.:  .||.|...:..:.|..|.|||::.:.:||..|
  Fly   245 RFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHAS 309

  Fly   463 DVWSYGILLMELFTYGQVPYPGMHSREVIENIER-GFRMPKPTNHYFPDNIYQLLLQCWDAVPEK 526
            |.|.:|:.|.|:|::|:.|:.|::..:::..|:| |.|:.:|  ...|.::|.::|||||..|.:
  Fly   310 DTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQP--DACPPDVYAMMLQCWDKTPAE 372

  Fly   527 RPTFEFLNHYFESFS 541
            ||||..|..|..|.|
  Fly   373 RPTFAALKEYLASMS 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779
		SH2_Src_family	158..259	CDD:199827	9/35 (26%)
		STYKc	285..537	CDD:214568	98/263 (37%)
		PTKc_Src_like	289..538	CDD:270630	98/260 (38%)
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	4/12 (33%)
		PTKc_Ack_like	128..385	CDD:270636	98/260 (38%)
		UBA_TNK1	1031..1070	CDD:270513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468362
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940