DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Fak

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster

Alignment Length:	315	Identity:	106/315 - (33%)
Similarity:	161/315 - (51%)	Gaps:	41/315 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 PELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKW----------------------RNS------I 308
            |.:|: ||:.|:.|....|:|.|.||:|:.|.:                      ||:      |
  Fly   445 PTVRN-YELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVI 508

  Fly   309 DVAVKTLR--EGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLRE 371
            .||:||.:  :....|..||.||.||:||.|..::.|..:|| ..||:||.|....|.|..:|:.
  Fly   509 QVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICS-VMPIWIVMELAKLGELRAYLKT 572

  Fly   372 GDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYC 436
            ...|..| ..|:....|:::.:.|||||:.:|||:||||||:......|:.||||:|.::|..|.
  Fly   573 NSERLSH-GTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYY 636

  Fly   437 PKQGS-RFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRM 500
            ....: ..|:||.:||:|.:.:|:..||||.:|:.:.|:...|..|:.|:.:.:||..:|.|.|:
  Fly   637 HSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERL 701

  Fly   501 PKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSV-----TSEVPYRE 550
            |.|.|  .|..:|.|:.|||...|.|||.|:.:........:     :||...||
  Fly   702 PLPPN--CPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKRE 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779
		SH2_Src_family	158..259	CDD:199827
		STYKc	285..537	CDD:214568	97/282 (34%)
		PTKc_Src_like	289..538	CDD:270630	96/279 (34%)
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011
		PTKc_FAK	450..744	CDD:133187	100/297 (34%)
		Pkinase_Tyr	462..736	CDD:285015	96/277 (35%)
		Focal_AT	1249..1376	CDD:281606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468366
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840