DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and JAK3

DIOPT Version :9

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_000206.2 Gene:JAK3 / 3718 HGNCID:6193 Length:1124 Species:Homo sapiens


Alignment Length:310 Identity:102/310 - (32%)
Similarity:158/310 - (50%) Gaps:36/310 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   255 ILSRPCP---KPQPQMWDLGPEL---RDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSID---- 309
            :||.|.|   .|:..:|: |.:|   :|........::.:.:||:||||.|...::....|    
Human   787 LLSDPTPGALAPRDGLWN-GAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGA 850

  Fly   310 -VAVKTLR-EGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQ---EEPIYIVQEYMSKGSLLDFL 369
             ||||.|: .|......|.:|..|:|.. |:..:..|...|.   .:.:.:|.||:..|.|.|||
Human   851 LVAVKQLQHSGPDQQRDFQREIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL 914

  Fly   370 REGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIA--D 432
            :....| |....|:..::|:..|||||.|::.:||||||||:|:......||.|||||:::.  .
Human   915 QRHRAR-LDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDK 978

  Fly   433 DEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTY------GQVPYPGMHSRE-- 489
            |.|..::..:.|:.|.|||::....||.:|||||:|::|.|||||      ....:..|...|  
Human   979 DYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERD 1043

  Fly   490 ------VIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
                  ::|.:|.|.|:|.|.  ..|..:::|:..||...|:.||:|..|
Human  1044 VPALCRLLELLEEGQRLPAPP--ACPAEVHELMKLCWAPSPQDRPSFSAL 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH3_Src_like 99..150 CDD:212779
SH2_Src_family 158..259 CDD:199827 2/3 (67%)
STYKc 285..537 CDD:214568 93/274 (34%)
PTKc_Src_like 289..538 CDD:270630 93/270 (34%)
JAK3NP_000206.2 Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 1..223
B41 39..>200 CDD:214604
PH-like 250..362 CDD:302622
SH2_Jak3 362..458 CDD:198243
PTK_Jak3_rpt1 521..778 CDD:271110
Pkinase_Tyr 521..777 CDD:285015
PTKc_Jak3_rpt2 817..1099 CDD:270665 93/279 (33%)
Pkinase_Tyr 822..1095 CDD:285015 93/274 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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